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Table of Contents: October 2009

COVER

Five-week-old juvenile gray mouse lemurs (Microcebus murinus) in a hollow tree in Kirindy Forest, Western Madagascar.

Image Credit: Manfred Eberle, www.phocus.org (German Primate Center - Leibniz Institute for Primate Research, Germany)
Issue Image

Lemurs are the most distantly related non-human primates. A Research Article by Anne Averdam and colleagues in this issue of PLoS Genetics (see Averdam et al., 10.1371/journal.pgen.1000688) shows that lemurs differ considerably from "higher" primates in receptors of natural killer (NK) cells and their ligands. Instead of KIR or Ly49 genes, lemurs substantially expanded and diversified CD94/NKG2 receptors. Remarkably, this novel system of polymorphic and diverse receptors points to combinatorial diversity as a mechanism to increase the NK cell receptor repertoire of lemurs, a finding that was previously unknown for NK cells.

Interview

Reviews

Research Articles

Dissection of the Complex Phenotype in Cuticular Mutants of Arabidopsis Reveals a Role of SERRATE as a Mediator

Derry Voisin, Christiane Nawrath, Sergey Kurdyukov, Rochus B. Franke, José J. Reina-Pinto, Nadia Efremova, Isa Will, Lukas Schreiber, Alexander Yephremov

Progressive GAA·TTC Repeat Expansion in Human Cell Lines

Scott Ditch, Mimi C. Sammarco, Ayan Banerjee, Ed Grabczyk

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

Anna M. Selmecki, Keely Dulmage, Leah E. Cowen, James B. Anderson, Judith Berman

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

Iris M. Heid, Cornelia Huth, Ruth J. F. Loos, Florian Kronenberg, Vera Adamkova, Sonia S. Anand, Kristin Ardlie, Heike Biebermann, Peter Bjerregaard, Heiner Boeing, Claude Bouchard, Marina Ciullo, Jackie A. Cooper, Dolores Corella, Christian Dina, James C. Engert, Eva Fisher, Francesc Francès, Philippe Froguel, Johannes Hebebrand, Robert A. Hegele, Anke Hinney, Margret R. Hoehe, Frank B. Hu, Jaroslav A. Hubacek, Steve E. Humphries, Steven C. Hunt, Thomas Illig, Marjo-Riita Järvelin, Marika Kaakinen, Barbara Kollerits, Heiko Krude, Jitender Kumar, Leslie A. Lange, Birgit Langer, Shengxu Li, Andreas Luchner, Helen N. Lyon, David Meyre, Karen L. Mohlke, Vincent Mooser, Almut Nebel, Thuy Trang Nguyen, Bernhard Paulweber, Louis Perusse, Lu Qi, Tuomo Rankinen, Dieter Rosskopf, Stefan Schreiber, Shantanu Sengupta, Rossella Sorice, Anita Suk, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Henry Völzke, Karani S. Vimaleswaran, Nicholas J. Wareham, Dawn Waterworth, Salim Yusuf, Cecilia Lindgren, Mark I. McCarthy, Christoph Lange, Joel N. Hirschhorn, Nan Laird, H.-Erich Wichmann

Inferring the Joint Demographic History of Multiple Populations from Multidimensional SNP Frequency Data

Ryan N. Gutenkunst, Ryan D. Hernandez, Scott H. Williamson, Carlos D. Bustamante

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

Lisa F. Barcellos, Suzanne L. May, Patricia P. Ramsay, Hong L. Quach, Julie A. Lane, Joanne Nititham, Janelle A. Noble, Kimberly E. Taylor, Diana L. Quach, Sharon A. Chung, Jennifer A. Kelly, Kathy L. Moser, Timothy W. Behrens, Michael F. Seldin, Glenys Thomson, John B. Harley, Patrick M. Gaffney, Lindsey A. Criswell

Quantifying Adaptive Evolution in the Drosophila Immune System

Darren J. Obbard, John J. Welch, Kang-Wook Kim, Francis M. Jiggins

Restricting Dosage Compensation Complex Binding to the X Chromosomes by H2A.Z/HTZ-1

Emily L. Petty, Karishma S. Collette, Alysse J. Cohen, Martha J. Snyder, Györgyi Csankovszki

Bruchpilot in Ribbon-Like Axonal Agglomerates, Behavioral Defects, and Early Death in SRPK79D Kinase Mutants of Drosophila

Vanessa Nieratschker, Alice Schubert, Mandy Jauch, Nicole Bock, Daniel Bucher, Sonja Dippacher, Georg Krohne, Esther Asan, Sigrid Buchner, Erich Buchner

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

Lukasz Wojtasz, Katrin Daniel, Ignasi Roig, Ewelina Bolcun-Filas, Huiling Xu, Verawan Boonsanay, Christian R. Eckmann, Howard J. Cooke, Maria Jasin, Scott Keeney, Michael J. McKay, Attila Toth

Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

Nicole Bennardo, Amanda Gunn, Anita Cheng, Paul Hasty, Jeremy M. Stark

Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging

Heather E. Wheeler, E. Jeffrey Metter, Toshiko Tanaka, Devin Absher, John Higgins, Jacob M. Zahn, Julie Wilhelmy, Ronald W. Davis, Andrew Singleton, Richard M. Myers, Luigi Ferrucci, Stuart K. Kim

The Euchromatic and Heterochromatic Landscapes Are Shaped by Antagonizing Effects of Transcription on H2A.Z Deposition

Sara Hardy, Pierre-Étienne Jacques, Nicolas Gévry, Audrey Forest, Marie-Ève Fortin, Liette Laflamme, Luc Gaudreau, François Robert

A Novel System of Polymorphic and Diverse NK Cell Receptors in Primates

Anne Averdam, Beatrix Petersen, Cornelia Rosner, Jennifer Neff, Christian Roos, Manfred Eberle, Fabienne Aujard, Claudia Münch, Werner Schempp, Mary Carrington, Takashi Shiina, Hidetoshi Inoko, Florian Knaust, Penny Coggill, Harminder Sehra, Stephan Beck, Laurent Abi-Rached, Richard Reinhardt, Lutz Walter

Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

M. Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J. Thornton, Richard Wilson, John F. Bateman, Richard Poulsom, Peter Arvan, Karl E. Kadler, Michael D. Briggs, Raymond P. Boot-Handford

Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State

Alice Gerrits, Yang Li, Bruno M. Tesson, Leonid V. Bystrykh, Ellen Weersing, Albertina Ausema, Bert Dontje, Xusheng Wang, Rainer Breitling, Ritsert C. Jansen, Gerald de Haan

FON2 SPARE1 Redundantly Regulates Floral Meristem Maintenance with FLORAL ORGAN NUMBER2 in Rice

Takuya Suzaki, Masako Ohneda, Taiyo Toriba, Akiko Yoshida, Hiro-Yuki Hirano

Life on Arginine for Mycoplasma hominis: Clues from Its Minimal Genome and Comparison with Other Human Urogenital Mycoplasmas

Sabine Pereyre, Pascal Sirand-Pugnet, Laure Beven, Alain Charron, Hélène Renaudin, Aurélien Barré, Philippe Avenaud, Daniel Jacob, Arnaud Couloux, Valérie Barbe, Antoine de Daruvar, Alain Blanchard, Cécile Bébéar

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes

Zhi Wei, Kai Wang, Hui-Qi Qu, Haitao Zhang, Jonathan Bradfield, Cecilia Kim, Edward Frackleton, Cuiping Hou, Joseph T. Glessner, Rosetta Chiavacci, Charles Stanley, Dimitri Monos, Struan F. A. Grant, Constantin Polychronakos, Hakon Hakonarson

Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells

Wei Zou, Qun Lu, Dongfeng Zhao, Weida Li, James Mapes, Yuting Xie, Xiaochen Wang

p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair

Yu-Li Lin, Shomit Sengupta, Katherine Gurdziel, George W. Bell, Tyler Jacks, Elsa R. Flores

Plasticity of the Chemoreceptor Repertoire in Drosophila melanogaster

Shanshan Zhou, Eric A. Stone, Trudy F. C. Mackay, Robert R. H. Anholt

Heterochromatin Protein 1 (HP1a) Positively Regulates Euchromatic Gene Expression through RNA Transcript Association and Interaction with hnRNPs in Drosophila

Lucia Piacentini, Laura Fanti, Rodolfo Negri, Valerio Del Vescovo, Alessandro Fatica, Fabio Altieri, Sergio Pimpinelli

Compensatory Evolution of Gene Regulation in Response to Stress by Escherichia coli Lacking RpoS

Daniel M. Stoebel, Karsten Hokamp, Michael S. Last, Charles J. Dorman

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

Andrew A. Hicks, Peter P. Pramstaller, Åsa Johansson, Veronique Vitart, Igor Rudan, Peter Ugocsai, Yurii Aulchenko, Christopher S. Franklin, Gerhard Liebisch, Jeanette Erdmann, Inger Jonasson, Irina V. Zorkoltseva, Cristian Pattaro, Caroline Hayward, Aaron Isaacs, Christian Hengstenberg, Susan Campbell, Carsten Gnewuch, A. CecileJ.W. Janssens, Anatoly V. Kirichenko, Inke R. König, Fabio Marroni, Ozren Polasek, Ayse Demirkan, Ivana Kolcic, Christine Schwienbacher, Wilmar Igl, Zrinka Biloglav, Jacqueline C. M. Witteman, Irene Pichler, Ghazal Zaboli, Tatiana I. Axenovich, Annette Peters, Stefan Schreiber, H.-Erich Wichmann, Heribert Schunkert, Nick Hastie, Ben A. Oostra, Sarah H. Wild, Thomas Meitinger, Ulf Gyllensten, Cornelia M. van Duijn, James F. Wilson, Alan Wright, Gerd Schmitz, Harry Campbell

Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

Chiara Giuliani, Flavia Troglio, Zhiyong Bai, Falshruti B. Patel, Adriana Zucconi, Maria Grazia Malabarba, Andrea Disanza, Theresia B. Stradal, Giuseppe Cassata, Stefano Confalonieri, Jeffrey D. Hardin, Martha C. Soto, Barth D. Grant, Giorgio Scita

Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

Chia Huey Ooi, Tatiana Ivanova, Jeanie Wu, Minghui Lee, Iain Beehuat Tan, Jiong Tao, Lindsay Ward, Jun Hao Koo, Veena Gopalakrishnan, Yansong Zhu, Lai Ling Cheng, Julian Lee, Sun Young Rha, Hyun Cheol Chung, Kumaresan Ganesan, Jimmy So, Khee Chee Soo, Dennis Lim, Weng Hoong Chan, Wai Keong Wong, David Bowtell, Khay Guan Yeoh, Heike Grabsch, Alex Boussioutas, Patrick Tan