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Table of Contents: February 2008

COVER

Blimp1:gfp primordial germ cells

Image Credit: Confocal micrograph provided by Susana Chuva de Sousa Lopes and Katsuhiko Hayashi
Issue Image

At embryonic day 7.5, most XX primordial germ cells show an inactive X chromosome like their somatic neighbour cells. Blimp1:gfp primordial germ cells (green) after 2 days of culture showing a distinct trimetylation of histone 3 on lysine 27 (H3K27me3) nuclear accumulation (pink) indicative of the inactive X chromosome (see Chuva de Sousa Lopes et al., e30).

Interview

Review

Research Articles

The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival

Debra L. Silver, Ling Hou, Robert Somerville, Mary E. Young, Suneel S. Apte, William J. Pavan

Variation in Molybdenum Content Across Broadly Distributed Populations of Arabidopsis thaliana Is Controlled by a Mitochondrial Molybdenum Transporter (MOT1)

Ivan Baxter, Balasubramaniam Muthukumar, Hyeong Cheol Park, Peter Buchner, Brett Lahner, John Danku, Keyan Zhao, Joohyun Lee, Malcolm J. Hawkesford, Mary Lou Guerinot, David E. Salt

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

Anthony Arnoldo, Jasna Curak, Saranya Kittanakom, Igor Chevelev, Vincent T. Lee, Mehdi Sahebol-Amri, Becky Koscik, Lana Ljuma, Peter J. Roy, Antonio Bedalov, Guri Giaever, Corey Nislow, Rod A. Merrill, Stephen Lory, Igor Stagljar

Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression

David Serre, Scott Gurd, Bing Ge, Robert Sladek, Donna Sinnett, Eef Harmsen, Marina Bibikova, Eugene Chudin, David L. Barker, Todd Dickinson, Jian-Bing Fan, Thomas J. Hudson

Genome-Wide Assessments Reveal Extremely High Levels of Polymorphism of Two Active Families of Mouse Endogenous Retroviral Elements

Ying Zhang, Irina A. Maksakova, Liane Gagnier, Louie N. van de Lagemaat, Dixie L. Mager

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

William G. Hill, Michael E. Goddard, Peter M. Visscher

Drosophila Histone Deacetylase-3 Controls Imaginal Disc Size through Suppression of Apoptosis

Changqi C. Zhu, Douglas J. Bornemann, David Zhitomirsky, Ellen L. Miller, Michael B. O'Connor, Jeffrey A. Simon

Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken

Jonas Eriksson, Greger Larson, Ulrika Gunnarsson, Bertrand Bed'hom, Michele Tixier-Boichard, Lina Strömstedt, Dominic Wright, Annemieke Jungerius, Addie Vereijken, Ettore Randi, Per Jensen, Leif Andersson

RSF Governs Silent Chromatin Formation via Histone H2Av Replacement

Kazuma Hanai, Hirofumi Furuhashi, Takashi Yamamoto, Koji Akasaka, Susumu Hirose

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

Kelly N. Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B. Coffin, Anna J. Knisely, Julian A. Simon, Edwin W. Rubel, David W. Raible

The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material

Stefan Taubert, Malene Hansen, Marc R. Van Gilst, Samantha B. Cooper, Keith R. Yamamoto

The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

Takayuki Kanazawa, Mauro D. Zappaterra, Ayako Hasegawa, Ashley P. Wright, Erin D. Newman-Smith, Karolyn F. Buttle, Kent McDonald, Carmen A. Mannella, Alexander M. van der Bliek

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon

Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women

Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X Chen, David A Collier, Nicholas J Craddock, Kenneth S Kendler, Tao Li, Michael O'Donovan, F. Anthony O'Neill, Michael J Owen, Dermot Walsh, Daniel R Weinberger, Cuie Sun, Jonathan Flint, Ariel Darvasi

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

Dirk A Kleinjan, Ruth M Bancewicz, Philippe Gautier, Ralf Dahm, Helia B Schonthaler, Giuseppe Damante, Anne Seawright, Ann M Hever, Patricia L Yeyati, Veronica van Heyningen, Pedro Coutinho

Adaptations to Climate in Candidate Genes for Common Metabolic Disorders

Angela M Hancock, David B Witonsky, Adam S Gordon, Gidon Eshel, Jonathan K Pritchard, Graham Coop, Anna Di Rienzo

Unintentional miRNA Ablation Is a Risk Factor in Gene Knockout Studies: A Short Report

Ivan Osokine, Ruby Hsu, Gabriel B Loeb, Michael T McManus

Motility Screen Identifies Drosophila IGF-II mRNA-Binding Protein—Zipcode-Binding Protein Acting in Oogenesis and Synaptogenesis

Kristin L. M Boylan, Sarah Mische, Mingang Li, Guillermo Marqués, Xavier Morin, William Chia, Thomas S Hays

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

Masayuki Kimura, Lynn F Cherkas, Bernet S Kato, Serkalem Demissie, Jacob B Hjelmborg, Michael Brimacombe, Adrienne Cupples, Janice L Hunkin, Jefferey P Gardner, Xiaobin Lu, Xiaojian Cao, Malinee Sastrasinh, Michael A Province, Steven C Hunt, Kaare Christensen, Daniel Levy, Tim D Spector, Abraham Aviv

Genome-Wide Expression of Azoospermia Testes Demonstrates a Specific Profile and Implicates ART3 in Genetic Susceptibility

Hiroyuki Okada, Atsushi Tajima, Kazuyoshi Shichiri, Atsushi Tanaka, Kenichi Tanaka, Ituro Inoue

Dynamic Regulation of ARGONAUTE4 within Multiple Nuclear Bodies in Arabidopsis thaliana

Carey F Li, Ian R Henderson, Liang Song, Nina Fedoroff, Thierry Lagrange, Steven E Jacobsen

X Chromosome Activity in Mouse XX Primordial Germ Cells

Susana M Chuva de Sousa Lopes, Katsuhiko Hayashi, Tanya C Shovlin, Will Mifsud, M. Azim Surani, Anne McLaren

ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta

Thomas S Lisse, Frank Thiele, Helmut Fuchs, Wolfgang Hans, Gerhard K. H Przemeck, Koichiro Abe, Birgit Rathkolb, Leticia Quintanilla-Martinez, Gabriele Hoelzlwimmer, Miep Helfrich, Eckhard Wolf, Stuart H Ralston, Martin Hrabé de Angelis

Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

Todd P Michael, Todd C Mockler, Ghislain Breton, Connor McEntee, Amanda Byer, Jonathan D Trout, Samuel P Hazen, Rongkun Shen, Henry D Priest, Christopher M Sullivan, Scott A Givan, Marcelo Yanovsky, Fangxin Hong, Steve A Kay, Joanne Chory

The Evolution of Spinnable Cotton Fiber Entailed Prolonged Development and a Novel Metabolism

Ran Hovav, Joshua A Udall, Bhupendra Chaudhary, Einat Hovav, Lex Flagel, Guanjing Hu, Jonathan F Wendel