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Table of Contents: June 2010

COVER

Winged form of the peach-potato aphid Myzus persicae.

Image Credit: Photograph courtesy of Rothamsted Research
Issue Image

The peach potato aphid Myzus persicae is the most economically important aphid pest in many regions of the world and has developed resistance to many classes of insecticide used for control. In this issue of PLoS Genetics, Puinean et al. made use of recent advances in genomics to quantify the expression of all genes encoding detoxification enzymes in an insecticide resistant strain of M. persicae. Resistance was associated with the over-expression of a single P450 gene, and the authors show, for the first time in an agriculturally important insect pest, that this is due to amplification of the gene.

Editorial

Consent and Internet-Enabled Human Genomics

Greg Gibson, Gregory P. Copenhaver

Perspective

Research Articles

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

Nicholas Eriksson, J. Michael Macpherson, Joyce Y. Tung, Lawrence S. Hon, Brian Naughton, Serge Saxonov, Linda Avey, Anne Wojcicki, Itsik Pe'er, Joanna Mountain

Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF–Dependent Transcription in Hypoxia

Andrés Dekanty, Nuria M. Romero, Agustina P. Bertolin, María G. Thomas, Claudia C. Leishman, Joel I. Perez-Perri, Graciela L. Boccaccio, Pablo Wappner

Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

Jeffrey C. Francis, Afshan McCarthy, Martin K. Thomsen, Alan Ashworth, Amanda Swain

Endoreplication Controls Cell Fate Maintenance

Jonathan Bramsiepe, Katja Wester, Christina Weinl, Farshad Roodbarkelari, Remmy Kasili, John C. Larkin, Martin Hülskamp, Arp Schnittger

Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

So-Yon Lim, Tiffany Chan, Rebecca S. Gelman, James B. Whitney, Kara L. O'Brien, Dan H. Barouch, David B. Goldstein, Barton F. Haynes, Norman L. Letvin

Copy Number Variation and Transposable Elements Feature in Recent, Ongoing Adaptation at the Cyp6g1 Locus

Joshua M. Schmidt, Robert T. Good, Belinda Appleton, Jayne Sherrard, Greta C. Raymant, Michael R. Bogwitz, Jon Martin, Phillip J. Daborn, Mike E. Goddard, Philip Batterham, Charles Robin

Amplification of a Cytochrome P450 Gene Is Associated with Resistance to Neonicotinoid Insecticides in the Aphid Myzus persicae

Alin M. Puinean, Stephen P. Foster, Linda Oliphant, Ian Denholm, Linda M. Field, Neil S. Millar, Martin S. Williamson, Chris Bass

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy

Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A. Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L. Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T. Neil Dear

Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium

Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Shimian Qu, Chun Li, Ying Zheng, Kai Gu, Wenjing Wang, Yong-Bing Xiang, Jiarong Cheng, Kexin Chen, Lina Zhang, Hong Zheng, Chen-Yang Shen, Chiun-Sheng Huang, Ming-Feng Hou, Hongbing Shen, Zhibin Hu, Furu Wang, Sandra L. Deming, Mark C. Kelley, Martha J. Shrubsole, Ui Soon Khoo, Kelvin Y. K. Chan, Sum Yin Chan, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Motoki Iwasaki, Yoshio Kasuga, Shoichiro Tsugane, Keitaro Matsuo, Kazuo Tajima, Hiroji Iwata, Bo Huang, Jiajun Shi, Guoliang Li, Wanqing Wen, Yu-Tang Gao, Wei Lu, Wei Zheng

Tandem E2F Binding Sites in the Promoter of the p107 Cell Cycle Regulator Control p107 Expression and Its Cellular Functions

Deborah L. Burkhart, Stacey E. Wirt, Anne-Flore Zmoos, Michael S. Kareta, Julien Sage

Translational Selection Is Ubiquitous in Prokaryotes

Fran Supek, Nives Škunca, Jelena Repar, Kristian Vlahoviček, Tomislav Šmuc

Dosage-Sensitive Function of RETINOBLASTOMA RELATED and Convergent Epigenetic Control Are Required during the Arabidopsis Life Cycle

Amal J. Johnston, Olga Kirioukhova, Philippa J. Barrell, Twan Rutten, James M. Moore, Ramamurthy Baskar, Ueli Grossniklaus, Wilhelm Gruissem

The CYCLIN-A CYCA1;2/TAM Is Required for the Meiosis I to Meiosis II Transition and Cooperates with OSD1 for the Prophase to First Meiotic Division Transition

Isabelle d'Erfurth, Laurence Cromer, Sylvie Jolivet, Chloé Girard, Christine Horlow, Yujin Sun, Jennifer P. C. To, Luke E. Berchowitz, Gregory P. Copenhaver, Raphael Mercier

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

Lutz Kockel, Kimberly S. Kerr, Michael Melnick, Katja Brückner, Matthias Hebrok, Norbert Perrimon

Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

Nara L. M. Sobreira, Elizabeth T. Cirulli, Dimitrios Avramopoulos, Elizabeth Wohler, Gretchen L. Oswald, Eric L. Stevens, Dongliang Ge, Kevin V. Shianna, Jason P. Smith, Jessica M. Maia, Curtis E. Gumbs, Jonathan Pevsner, George Thomas, David Valle, Julie E. Hoover-Fong, David B. Goldstein

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

Masayo Kagami, Maureen J. O'Sullivan, Andrew J. Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C. Ferguson-Smith, Tsutomu Ogata

An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Serkalem Demissie, Nicole Soranzo, Estelle N. Bianchi, Elin Grundberg, Liming Liang, J. Brent Richards, Karol Estrada, Yanhua Zhou, Atila van Nas, Miriam F. Moffatt, Guangju Zhai, Albert Hofman, Joyce B. van Meurs, Huibert A. P. Pols, Roger I. Price, Olle Nilsson, Tomi Pastinen, L. Adrienne Cupples, Aldons J. Lusis, Eric E. Schadt, Serge Ferrari, André G. Uitterlinden, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

A Genome-Wide Association Study of Optic Disc Parameters

Wishal D. Ramdas, Leonieke M. E. van Koolwijk, M. Kamran Ikram, Nomdo M. Jansonius, Paulus T. V. M. de Jong, Arthur A. B. Bergen, Aaron Isaacs, Najaf Amin, Yurii S. Aulchenko, Roger C. W. Wolfs, Albert Hofman, Fernando Rivadeneira, Ben A. Oostra, Andre G. Uitterlinden, Pirro Hysi, Christopher J. Hammond, Hans G. Lemij, Johannes R. Vingerling, Caroline C. W. Klaver, Cornelia M. van Duijn

The Transcription Factor REST Is Lost in Aggressive Breast Cancer

Matthew P. Wagoner, Kearney T. W. Gunsalus, Barry Schoenike, Andrea L. Richardson, Andreas Friedl, Avtar Roopra

Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice

Isabelle Sahut-Barnola, Cyrille de Joussineau, Pierre Val, Sarah Lambert-Langlais, Christelle Damon, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Geoffroy Marceau, Vincent Sapin, Frédérique Tissier, Bruno Ragazzon, Jérôme Bertherat, Lawrence S. Kirschner, Constantine A. Stratakis, Antoine Martinez

Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State

Tae-Jin Lee, Pete E. Pascuzzi, Sharon B. Settlage, Randall W. Shultz, Milos Tanurdzic, Pablo D. Rabinowicz, Margit Menges, Ping Zheng, Dorrie Main, James A. H. Murray, Bryon Sosinski, George C. Allen, Robert A. Martienssen, Linda Hanley-Bowdoin, Matthew W. Vaughn, William F. Thompson

The E1A-Associated p400 Protein Modulates Cell Fate Decisions by the Regulation of ROS Homeostasis

Lise Mattera, Céline Courilleau, Gaëlle Legube, Takeshi Ueda, Rikiro Fukunaga, Martine Chevillard-Briet, Yvan Canitrot, Fabrice Escaffit, Didier Trouche

Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis Via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10

Misti C. White, Rui Gao, Weidong Xu, Santi M. Mandal, Jung G. Lim, Tapas K. Hazra, Maki Wakamiya, Sharon F. Edwards, Salmo Raskin, Hélio A. G. Teive, Huda Y. Zoghbi, Partha S. Sarkar, Tetsuo Ashizawa

Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

Amir N. Saleem, Yen-Hui Chen, Hwa Jin Baek, Ya-Wen Hsiao, Hong-Wen Huang, Hsiao-Jung Kao, Kai-Ming Liu, Li-Fen Shen, I-wen Song, Chen-Pei D. Tu, Jer-Yuarn Wu, Tateki Kikuchi, Monica J. Justice, Jeffrey J. Y. Yen, Yuan-Tsong Chen

siRNA–Mediated Methylation of Arabidopsis Telomeres

Jan Vrbsky, Svetlana Akimcheva, J. Matthew Watson, Thomas L. Turner, Lucia Daxinger, Boris Vyskot, Werner Aufsatz, Karel Riha

The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate

Gülüm Kosova, Joseph K. Pickrell, Joanna L. Kelley, Patrick F. McArdle, Alan R. Shuldiner, Mark Abney, Carole Ober

14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila

Caline S. Karam, Wendy A. Kellner, Naomi Takenaka, Alexa W. Clemmons, Victor G. Corces

Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes

Jussi Naukkarinen, Ida Surakka, Kirsi H. Pietiläinen, Aila Rissanen, Veikko Salomaa, Samuli Ripatti, Hannele Yki-Järvinen, Cornelia M. van Duijn, H.-Erich Wichmann, Jaakko Kaprio, Marja-Riitta Taskinen, Leena Peltonen , ENGAGE Consortium