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Table of Contents: April 2010

COVER

Gut decisions.

Image Credit: Adam J. Siegel (School of Life Sciences, Arizona State University, USA)
Issue Image

Honey bees make food choices when visiting flowering plants. Some bees prefer carbohydrate-rich nectar; others choose pollen high in protein. Similar food decisions are partly responsible for metabolic disorders in humans, such as diabetes and obesity. In this issue of PLoS Genetics, Wang et al. show that food-choice behavior in bees is regulated by abdominal fat cells through the gene IRS (Insulin Receptor Substrate), a conserved gene central to animal metabolic biology. While IRS activity in the brain was previously implicated in animal appetitive behavior, these results show IRS can act in non-neural tissues to modify food choice.

Perspective

The Next Generation Becomes the Now Generation

Diego A. Martinez, Mary Anne Nelson

Research Articles

Absence of Evidence for MHC–Dependent Mate Selection within HapMap Populations

Adnan Derti, Can Cenik, Peter Kraft, Frederick P. Roth

Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark

Reinhard Brunmeir, Sabine Lagger, Elisabeth Simboeck, Anna Sawicka, Gerda Egger, Astrid Hagelkruys, Yu Zhang, Patrick Matthias, Wolfgang J. Miller, Christian Seiser

Genome-Wide Association Study of Lp-PLA2 Activity and Mass in the Framingham Heart Study

Sunil Suchindran, David Rivedal, John R. Guyton, Tom Milledge, Xiaoyi Gao, Ashlee Benjamin, Jennifer Rowell, Geoffrey S. Ginsburg, Jeanette J. McCarthy

Genetic Evidence for Hybrid Trait Speciation in Heliconius Butterflies

Camilo Salazar, Simon W. Baxter, Carolina Pardo-Diaz, Grace Wu, Alison Surridge, Mauricio Linares, Eldredge Bermingham, Chris D. Jiggins

Natural Single-Nucleosome Epi-Polymorphisms in Yeast

Muniyandi Nagarajan, Jean-Baptiste Veyrieras, Maud de Dieuleveult, Hélène Bottin, Steffen Fehrmann, Anne-Laure Abraham, Séverine Croze, Lars M. Steinmetz, Xavier Gidrol, Gaël Yvert

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

Donglai Sheng, Dianbo Qu, Ken Hon Hung Kwok, Seok Shin Ng, Adrian Yin Ming Lim, Sharon Siqi Aw, Charlie Wah Heng Lee, Wing Kin Sung, Eng King Tan, Thomas Lufkin, Suresh Jesuthasan, Mathavan Sinnakaruppan, Jianjun Liu

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, Carla I. G. Vogel, Timo D. Müller, Harald Grallert, H.-Erich Wichmann, Beverley Balkau, Barbara Heude, Marjo-Riitta Jarvelin, Anna-Liisa Hartikainen, Claire Levy-Marchal, Jacques Weill, Jérôme Delplanque, Antje Körner, Wieland Kiess, Peter Kovacs, Nigel W. Rayner, Inga Prokopenko, Mark I. McCarthy, Helmut Schäfer, Ivonne Jarick, Heiner Boeing, Eva Fisher, Thomas Reinehr, Joachim Heinrich, Peter Rzehak, Dietrich Berdel, Michael Borte, Heike Biebermann, Heiko Krude, Dieter Rosskopf, Christian Rimmbach, Winfried Rief, Tobias Fromme, Martin Klingenspor, Annette Schürmann, Nadja Schulz, Markus M. Nöthen, Thomas W. Mühleisen, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Tanja Boes, Thomas Illig, Philippe Froguel, Johannes Hebebrand, David Meyre

Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer

Erika M. Wolff, Hyang-Min Byun, Han F. Han, Shikhar Sharma, Peter W. Nichols, Kimberly D. Siegmund, Allen S. Yang, Peter A. Jones, Gangning Liang

Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina

Brandon N. Nicolay, Battuya Bayarmagnai, Nam Sung Moon, Elizaveta V. Benevolenskaya, Maxim V. Frolov

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization

Nausica Arnoult, Caroline Schluth-Bolard, Anne Letessier, Irena Drascovic, Rachida Bouarich-Bourimi, Judith Campisi, Sahn-ho Kim, Amina Boussouar, Alexandre Ottaviani, Frédérique Magdinier, Eric Gilson, Arturo Londoño-Vallejo

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

Mirela Matecic, Daniel L. Smith Jr, Xuewen Pan, Nazif Maqani, Stefan Bekiranov, Jef D. Boeke, Jeffrey S. Smith

Activation of Estrogen-Responsive Genes Does Not Require Their Nuclear Co-Localization

Silvia Kocanova, Elizabeth A. Kerr, Sehrish Rafique, Shelagh Boyle, Elad Katz, Stephanie Caze-Subra, Wendy A. Bickmore, Kerstin Bystricky

Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death

Mellone N. Marchong, Christine Yurkowski, Clement Ma, Clarellen Spencer, Sanja Pajovic, Brenda L. Gallie

Genetic Analysis of Fin Development in Zebrafish Identifies Furin and Hemicentin1 as Potential Novel Fraser Syndrome Disease Genes

Thomas J. Carney, Natália Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M. Gebauer, Jared Coffin Talbot, Charles B. Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W. Ingham, Matthias Hammerschmidt

Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) Study

Ching-Yu Cheng, David Reich, Tien Y. Wong, Ronald Klein, Barbara E. K. Klein, Nick Patterson, Arti Tandon, Man Li, Eric Boerwinkle, A. Richey Sharrett, W. H. Linda Kao

Whole-Genome SNP Association in the Horse: Identification of a Deletion in Myosin Va Responsible for Lavender Foal Syndrome

Samantha A. Brooks, Nicole Gabreski, Donald Miller, Abra Brisbin, Helen E. Brown, Cassandra Streeter, Jason Mezey, Deborah Cook, Douglas F. Antczak

Actin-Related Protein Arp6 Influences H2A.Z-Dependent and -Independent Gene Expression and Links Ribosomal Protein Genes to Nuclear Pores

Takahito Yoshida, Kenji Shimada, Yukako Oma, Véronique Kalck, Kazumi Akimura, Angela Taddei, Hitoshi Iwahashi, Kazuto Kugou, Kunihiro Ohta, Susan M. Gasser, Masahiko Harata

The Five AhMTP1 Zinc Transporters Undergo Different Evolutionary Fates towards Adaptive Evolution to Zinc Tolerance in Arabidopsis halleri

Zaigham Shahzad, Françoise Gosti, Hélène Frérot, Eric Lacombe, Nancy Roosens, Pierre Saumitou-Laprade, Pierre Berthomieu

A cis-Regulatory Signature for Chordate Anterior Neuroectodermal Genes

Maximilian Haeussler, Yan Jaszczyszyn, Lionel Christiaen, Jean-Stéphane Joly

De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model Organism for Fungal Morphogenesis

Minou Nowrousian, Jason E. Stajich, Meiling Chu, Ines Engh, Eric Espagne, Karen Halliday, Jens Kamerewerd, Frank Kempken, Birgit Knab, Hsiao-Che Kuo, Heinz D. Osiewacz, Stefanie Pöggeler, Nick D. Read, Stephan Seiler, Kristina M. Smith, Denise Zickler, Ulrich Kück, Michael Freitag

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

Yuping Luo, Ge Shan, Weixiang Guo, Richard D. Smrt, Eric B. Johnson, Xuekun Li, Rebecca L. Pfeiffer, Keith E. Szulwach, Ranhui Duan, Basam Z. Barkho, Wendi Li, Changmei Liu, Peng Jin, Xinyu Zhao

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

Michael S. Cunnington, Mauro Santibanez Koref, Bongani M. Mayosi, John Burn, Bernard Keavney

S Phase Progression in Human Cells Is Dictated by the Genetic Continuity of DNA Foci

Apolinar Maya-Mendoza, Pedro Olivares-Chauvet, Alex Shaw, Dean A. Jackson

Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development

Antonella Galli, Dimitri Robay, Marco Osterwalder, Xiaozhong Bao, Jean-Denis Bénazet, Muhammad Tariq, Renato Paro, Susan Mackem, Rolf Zeller

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Yulan Xiong, Candice E. Coombes, Austin Kilaru, Xiaojie Li, Aaron D. Gitler, William J. Bowers, Valina L. Dawson, Ted M. Dawson, Darren J. Moore

MicroRNA–Directed siRNA Biogenesis in Caenorhabditis elegans

Régis L. Corrêa, Florian A. Steiner, Eugene Berezikov, René F. Ketting

Cyclic Expression of Lhx2 Regulates Hair Formation

Gunilla Törnqvist, Anna Sandberg, Anna-Carin Hägglund, Leif Carlsson

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

Dan L. Nicolae, Eric Gamazon, Wei Zhang, Shiwei Duan, M. Eileen Dolan, Nancy J. Cox

Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans

Robert P. Shivers, Daniel J. Pagano, Tristan Kooistra, Claire E. Richardson, Kirthi C. Reddy, Janelle K. Whitney, Odile Kamanzi, Kunihiro Matsumoto, Naoki Hisamoto, Dennis H. Kim

Incipient Balancing Selection through Adaptive Loss of Aquaporins in Natural Saccharomyces cerevisiae Populations

Jessica L. Will, Hyun Seok Kim, Jessica Clarke, John C. Painter, Justin C. Fay, Audrey P. Gasch

Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations

Alexandra C. Nica, Stephen B. Montgomery, Antigone S. Dimas, Barbara E. Stranger, Claude Beazley, Inês Barroso, Emmanouil T. Dermitzakis

Down-Regulation of Honey Bee IRS Gene Biases Behavior toward Food Rich in Protein

Ying Wang, Navdeep S. Mutti, Kate E. Ihle, Adam Siegel, Adam G. Dolezal, Osman Kaftanoglu, Gro V. Amdam

A Pax3/Dmrt2/Myf5 Regulatory Cascade Functions at the Onset of Myogenesis

Takahiko Sato, Didier Rocancourt, Luís Marques, Sólveig Thorsteinsdóttir, Margaret Buckingham