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Table of Contents: April 2008

COVER

Image Credit: Photographs by Youssef Idaghdour
Issue Image
Environmental geographic effect on the human leukocyte transcriptome

A composite photo showing two distinct traditional lifestyles in different geographic contexts experienced by Moroccan Amazighs: desert nomadic (upper) and mountain agrarian (lower). Regional population differences, including lifestyle, geography, and biotic factors, can play at least as great a role as genetic divergence in modulating gene expression variation in humans (see Idaghdour et al., 10.1371/journal.pgen.1000052).

Special Report

SNPs Meet CNVs in Genome-Wide Association Studies: HGV2007 Meeting Report

Xavier Estivill, Nancy J. Cox, Stephen J. Chanock, Pui-Yan Kwok, Stephen W. Scherer, Anthony J. Brookes

Review

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

Michelle M. A. Fernando, Christine R. Stevens, Emily C. Walsh, Philip L. De Jager, Philippe Goyette, Robert M. Plenge, Timothy J. Vyse, John D. Rioux

Research Articles

An Increase in Mitochondrial DNA Promotes Nuclear DNA Replication in Yeast

Heidi M. Blank, Chonghua Li, John E. Mueller, Lydia M. Bogomolnaya, Mary Bryk, Michael Polymenis

Global Transcriptome and Deletome Profiles of Yeast Exposed to Transition Metals

Yong Hwan Jin, Paul E. Dunlap, Sandra J. McBride, Hanan Al-Refai, Pierre R. Bushel, Jonathan H. Freedman

Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics

Montserrat Garcia-Closas, Per Hall, Heli Nevanlinna, Karen Pooley, Jonathan Morrison, Douglas A. Richesson, Stig E. Bojesen, Børge G. Nordestgaard, Christen K. Axelsson, Jose I. Arias, Roger L. Milne, Gloria Ribas, Anna González-Neira, Javier Benítez, Pilar Zamora, Hiltrud Brauch, Christina Justenhoven, Ute Hamann, Yon-Dschun Ko, Thomas Bruening, Susanne Haas, Thilo Dörk, Peter Schürmann, Peter Hillemanns, Natalia Bogdanova, Michael Bremer, Johann Hinrich Karstens, Rainer Fagerholm, Kirsimari Aaltonen, Kristiina Aittomäki, Karl von Smitten, Carl Blomqvist, Arto Mannermaa, Matti Uusitupa, Matti Eskelinen, Maria Tengström, Veli-Matti Kosma, Vesa Kataja, Georgia Chenevix-Trench, Amanda B. Spurdle, Jonathan Beesley, Xiaoqing Chen, Australian Ovarian Cancer Management Group, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter Devilee, Christi J. van Asperen, Catharina E. Jacobi, Rob A. E. M. Tollenaar, Petra E.A. Huijts, Jan G. M. Klijn, Jenny Chang-Claude, Silke Kropp, Tracy Slanger, Dieter Flesch-Janys, Elke Mutschelknauss, Ramona Salazar, Shan Wang-Gohrke, Fergus Couch, Ellen L. Goode, Janet E. Olson, Celine Vachon, Zachary S. Fredericksen, Graham G. Giles, Laura Baglietto, Gianluca Severi, John L. Hopper, Dallas R. English, Melissa C. Southey, Christopher A. Haiman, Brian E. Henderson, Laurence N. Kolonel, Loic Le Marchand, Daniel O. Stram, David J. Hunter, Susan E. Hankinson, David G. Cox, Rulla Tamimi, Peter Kraft, Mark E. Sherman, Stephen J. Chanock, Jolanta Lissowska, Louise A. Brinton, Beata Peplonska, Jan G. M. Klijn, Maartje J. Hooning, Han Meijers-Heijboer, J. Margriet Collee, Ans van den Ouweland, Andre G. Uitterlinden, Jianjun Liu, Low Yen Lin, Li Yuqing, Keith Humphreys, Kamila Czene, Angela Cox, Sabapathy P. Balasubramanian, Simon S. Cross, Malcolm W. R. Reed, Fiona Blows, Kristy Driver, Alison Dunning, Jonathan Tyrer, Bruce A. J. Ponder, Suleeporn Sangrajrang, Paul Brennan, James McKay, Fabrice Odefrey, Valerie Gabrieau, Alice Sigurdson, Michele Doody, Jeffrey P. Struewing, Bruce Alexander, Douglas F. Easton, Paul D. Pharoah

Small RNA-Directed Epigenetic Natural Variation in Arabidopsis thaliana

Jixian Zhai, Jun Liu, Bin Liu, Pingchuan Li, Blake C. Meyers, Xuemei Chen, Xiaofeng Cao

Identification of CIITA Regulated Genetic Module Dedicated for Antigen Presentation

Michal Krawczyk, Queralt Seguín-Estévez, Elisa Leimgruber, Peter Sperisen, Christoph Schmid, Philipp Bucher, Walter Reith

Coordinated Regulation of Intestinal Functions in C. elegans by LIN-35/Rb and SLR-2

Natalia V. Kirienko, John D. K. McEnerney, David S. Fay

Primary Coenzyme Q Deficiency in Pdss2 Mutant Mice Causes Isolated Renal Disease

Min Peng, Marni J. Falk, Volker H. Haase, Rhonda King, Erzsebet Polyak, Mary Selak, Marc Yudkoff, Wayne W. Hancock, Ray Meade, Ryoichi Saiki, Adam L. Lunceford, Catherine F. Clarke, David L. Gasser

β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

Alla Buzina, Mandy Y. M. Lo, Angela Moffett, Akitsu Hotta, Eden Fussner, Rikki R. Bharadwaj, Peter Pasceri, J. Victor Garcia-Martinez, David P. Bazett-Jones, James Ellis

Analysis of Chimpanzee History Based on Genome Sequence Alignments

Jennifer L. Caswell, Swapan Mallick, Daniel J. Richter, Julie Neubauer, Christine Schirmer, Sante Gnerre, David Reich

Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus

Natalie D. Fedorova, Nora Khaldi, Vinita S. Joardar, Rama Maiti, Paolo Amedeo, Michael J. Anderson, Jonathan Crabtree, Joana C. Silva, Jonathan H. Badger, Ahmed Albarraq, Sam Angiuoli, Howard Bussey, Paul Bowyer, Peter J. Cotty, Paul S. Dyer, Amy Egan, Kevin Galens, Claire M. Fraser-Liggett, Brian J. Haas, Jason M. Inman, Richard Kent, Sebastien Lemieux, Iran Malavazi, Joshua Orvis, Terry Roemer, Catherine M. Ronning, Jaideep P. Sundaram, Granger Sutton, Geoff Turner, J. Craig Venter, Owen R. White, Brett R. Whitty, Phil Youngman, Kenneth H. Wolfe, Gustavo H. Goldman, Jennifer R. Wortman, Bo Jiang, David W. Denning, William C. Nierman

Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait

Juliet Ansel, Hélène Bottin, Camilo Rodriguez-Beltran, Christelle Damon, Muniyandi Nagarajan, Steffen Fehrmann, Jean François, Gaël Yvert

Bmp4 Is Essential for the Formation of the Vestibular Apparatus that Detects Angular Head Movements

Weise Chang, Zhengshi Lin, Holger Kulessa, Jean Hebert, Brigid L. M. Hogan, Doris K. Wu

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

Ying Liu, Cynthia Helms, Wilson Liao, Lisa C. Zaba, Shenghui Duan, Jennifer Gardner, Carol Wise, Andrew Miner, M. J. Malloy, Clive R. Pullinger, John P. Kane, Scott Saccone, Jane Worthington, Ian Bruce, Pui–Yan Kwok, Alan Menter, James Krueger, Anne Barton, Nancy L. Saccone, Anne M. Bowcock

Evolution and Control of Imprinted FWA Genes in the Genus Arabidopsis

Ryo Fujimoto, Yuki Kinoshita, Akira Kawabe, Tetsu Kinoshita, Kazuya Takashima, Magnus Nordborg, Mikhail E. Nasrallah, Kentaro K. Shimizu, Hiroshi Kudoh, Tetsuji Kakutani