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Research Article

RNA Editome in Rhesus Macaque Shaped by Purifying Selection

  • Jia-Yu Chen equal contributor,

    equal contributor Contributed equally to this work with: Jia-Yu Chen, Zhiyu Peng, Rongli Zhang

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Zhiyu Peng equal contributor,

    equal contributor Contributed equally to this work with: Jia-Yu Chen, Zhiyu Peng, Rongli Zhang

    Affiliations: BGI-Guangzhou, Guangzhou, China, BGI-Shenzhen, Shenzhen, China

    X
  • Rongli Zhang equal contributor,

    equal contributor Contributed equally to this work with: Jia-Yu Chen, Zhiyu Peng, Rongli Zhang

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Xin-Zhuang Yang,

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Bertrand Chin-Ming Tan,

    Affiliation: Department of Biomedical Sciences and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

    X
  • Huaying Fang,

    Affiliation: School of Mathematical Sciences and Center for Quantitative Biology, Peking University, Beijing, China

    X
  • Chu-Jun Liu,

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Mingming Shi,

    Affiliation: BGI-Shenzhen, Shenzhen, China

    X
  • Zhi-Qiang Ye,

    Affiliation: Lab of Computational Chemistry and Drug Design, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China

    X
  • Yong E. Zhang,

    Affiliation: Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

    X
  • Minghua Deng,

    Affiliation: School of Mathematical Sciences and Center for Quantitative Biology, Peking University, Beijing, China

    X
  • Xiuqin Zhang mail,

    zhangxq@pku.edu.cn (XZ); chuanyunli@pku.edu.cn (CYL)

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Chuan-Yun Li mail

    zhangxq@pku.edu.cn (XZ); chuanyunli@pku.edu.cn (CYL)

    Affiliation: Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Published: April 10, 2014
  • DOI: 10.1371/journal.pgen.1004274

About the Authors

Jia-Yu Chen, Rongli Zhang, Xin-Zhuang Yang, Chu-Jun Liu, Xiuqin Zhang, Chuan-Yun Li
Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China
Zhiyu Peng
BGI-Guangzhou, Guangzhou, China
Zhiyu Peng, Mingming Shi
BGI-Shenzhen, Shenzhen, China
Bertrand Chin-Ming Tan
Department of Biomedical Sciences and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Huaying Fang, Minghua Deng
School of Mathematical Sciences and Center for Quantitative Biology, Peking University, Beijing, China
Zhi-Qiang Ye
Lab of Computational Chemistry and Drug Design, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Yong E. Zhang
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CYL XZ. Performed the experiments: JYC XZY ZP RZ CJL MS BCMT. Analyzed the data: JYC XZY HF ZQY YEZ MD CJL MS ZP. Contributed reagents/materials/analysis tools: RZ HF MD. Wrote the paper: CYL JYC BCMT. Conceived the idea: CYL.