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Research Article

Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples

  • Peter M. Visscher mail,

    peter.visscher@uq.edu.au (PMV); jian.yang@uq.edu.au (JY)

    Affiliations: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia, The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland, Australia

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  • Gibran Hemani,

    Affiliations: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia, The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland, Australia

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  • Anna A. E. Vinkhuyzen,

    Affiliation: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia

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  • Guo-Bo Chen,

    Affiliation: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia

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  • Sang Hong Lee,

    Affiliation: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia

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  • Naomi R. Wray,

    Affiliation: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia

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  • Michael E. Goddard,

    Affiliations: University of Melbourne, Department of Food and Agricultural Systems, Parkville, Victoria, Australia, Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria, Australia

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  • Jian Yang mail

    peter.visscher@uq.edu.au (PMV); jian.yang@uq.edu.au (JY)

    Affiliations: The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia, The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland, Australia

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  • Published: April 10, 2014
  • DOI: 10.1371/journal.pgen.1004269

About the Authors

Peter M. Visscher, Gibran Hemani, Anna A. E. Vinkhuyzen, Guo-Bo Chen, Sang Hong Lee, Naomi R. Wray, Jian Yang
The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
Peter M. Visscher, Gibran Hemani, Jian Yang
The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland, Australia
Michael E. Goddard
University of Melbourne, Department of Food and Agricultural Systems, Parkville, Victoria, Australia
Michael E. Goddard
Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMV JY. Performed the experiments: JY PMV MEG. Analyzed the data: JY PMV. Contributed reagents/materials/analysis tools: NRW SHL AAEV GBC. Wrote the paper: PMV JY. Developed the online tool: GH JY.