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Research Article

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking

  • Robert J. Lake equal contributor,

    equal contributor Contributed equally to this work with: Robert J. Lake, Pei-Fang Tsai

    Affiliation: Epigenetics Program, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Pei-Fang Tsai equal contributor,

    equal contributor Contributed equally to this work with: Robert J. Lake, Pei-Fang Tsai

    Affiliation: Epigenetics Program, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Inchan Choi,

    Affiliations: Institute for Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Kyoung-Jae Won mail,

    wonk@mail.med.upenn.edu (KJW); hfan@mail.med.upenn.edu (HYF)

    Affiliations: Institute for Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Hua-Ying Fan mail

    wonk@mail.med.upenn.edu (KJW); hfan@mail.med.upenn.edu (HYF)

    Affiliations: Epigenetics Program, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.pgen.1004204

About the Authors

Robert J. Lake, Pei-Fang Tsai, Hua-Ying Fan
Epigenetics Program, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Inchan Choi, Kyoung-Jae Won, Hua-Ying Fan
Institute for Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Inchan Choi, Kyoung-Jae Won, Hua-Ying Fan
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RJL PFT HYF. Performed the experiments: RJL PFT HYF. Analyzed the data: RJL PFT IC KJW HYF. Contributed reagents/materials/analysis tools: RJL PFT IC KJW. Wrote the paper: RJL HYF.