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Research Article

Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis

  • Johan L. M. Björkegren,

    Affiliations: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Cardiovascular Genomics Group, Department of Pathological Anatomy and Forensic Medicine, University of Tartu, Tartu, Estonia, Institute for Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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  • Sara Hägg,

    Affiliations: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

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  • Husain A. Talukdar equal contributor,

    equal contributor Contributed equally to this work with: Husain A. Talukdar, Hassan Foroughi Asl

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Hassan Foroughi Asl equal contributor,

    equal contributor Contributed equally to this work with: Husain A. Talukdar, Hassan Foroughi Asl

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Rajeev K. Jain,

    Affiliation: Cardiovascular Genomics Group, Department of Pathological Anatomy and Forensic Medicine, University of Tartu, Tartu, Estonia

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  • Cecilia Cedergren,

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Ming-Mei Shang,

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Aránzazu Rossignoli,

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Rabbe Takolander,

    Affiliation: Department of Surgery, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

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  • Olle Melander,

    Affiliation: Department of Clinical Sciences, Hypertension & Cardiovascular Disease, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

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  • Anders Hamsten,

    Affiliation: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Tom Michoel,

    Affiliations: Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany, The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom

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  • Josefin Skogsberg mail

    Josefin.Skogsberg@ki.se

    Affiliation: Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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  • Published: February 27, 2014
  • DOI: 10.1371/journal.pgen.1004201

About the Authors

Johan L. M. Björkegren, Husain A. Talukdar, Hassan Foroughi Asl, Cecilia Cedergren, Ming-Mei Shang, Aránzazu Rossignoli, Josefin Skogsberg
Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Johan L. M. Björkegren, Rajeev K. Jain
Cardiovascular Genomics Group, Department of Pathological Anatomy and Forensic Medicine, University of Tartu, Tartu, Estonia
Johan L. M. Björkegren
Institute for Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
Sara Hägg
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sara Hägg
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Rabbe Takolander
Department of Surgery, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
Olle Melander
Department of Clinical Sciences, Hypertension & Cardiovascular Disease, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden
Anders Hamsten
Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Tom Michoel
Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany
Tom Michoel
The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom

Corresponding Author

Email: Josefin.Skogsberg@ki.se

Competing Interests

The authors have declared that no competing interests exist. JLMB is founder, main shareholder and chairman of the board for Clinical Gene Networks AB (CGN) and TM is shareholder. CGN has, however, no current commercial interest or rights in relations to the results presented in this manuscript.

Author Contributions

Conceived and designed the experiments: JS JLMB. Performed the experiments: JS RKJ CC MMS AR RT. Analyzed the data: JS SH HAT HFA OM TM. Contributed reagents/materials/analysis tools: AH. Wrote the paper: JS JLMB.