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Research Article

Gene-Based Sequencing Identifies Lipid-Influencing Variants with Ethnicity-Specific Effects in African Americans

  • Amy R. Bentley mail,

    amy.bentley@mail.nih.gov (ARB); rotimic@mail.nih.gov (CNR)

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Guanjie Chen,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Daniel Shriner,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ayo P. Doumatey,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jie Zhou,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Hanxia Huang,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • James C. Mullikin,

    Affiliation: National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Robert W. Blakesley,

    Affiliation: National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nancy F. Hansen,

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Gerard G. Bouffard,

    Affiliation: National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Praveen F. Cherukuri,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Baishali Maskeri,

    Affiliation: National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Alice C. Young,

    Affiliation: National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Adebowale Adeyemo,

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Charles N. Rotimi mail

    amy.bentley@mail.nih.gov (ARB); rotimic@mail.nih.gov (CNR)

    Affiliation: Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.pgen.1004190

About the Authors

Amy R. Bentley, Guanjie Chen, Daniel Shriner, Ayo P. Doumatey, Jie Zhou, Hanxia Huang, Adebowale Adeyemo, Charles N. Rotimi
Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
James C. Mullikin, Robert W. Blakesley, Gerard G. Bouffard, Baishali Maskeri, Alice C. Young
National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Nancy F. Hansen
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Praveen F. Cherukuri
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ARB AA CNR. Performed the experiments: APD HH JCM RWB NFH GGB PFC BM ACY. Analyzed the data: ARB GC DS JZ AA. Contributed reagents/materials/analysis tools: GC JCM. Wrote the paper: ARB AA CNR.