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Research Article

Parallel Evolution of Chordate Cis-Regulatory Code for Development

  • Laura Doglio,

    Affiliation: Systems Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Debbie K. Goode,

    Affiliation: Dept. of Haematology, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Maria C. Pelleri,

    Affiliation: Center for Research in Molecular Genetics Fondazione CARISBO, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy

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  • Stefan Pauls,

    Affiliation: Systems Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Flavia Frabetti,

    Affiliation: Center for Research in Molecular Genetics Fondazione CARISBO, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy

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  • Sebastian M. Shimeld,

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Tanya Vavouri mail,

    tvavouri@imppc.org (TV); gelgar@nimr.mrc.ac.uk (GE)

    Affiliation: Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Badalona, Barcelona, Spain

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  • Greg Elgar mail

    tvavouri@imppc.org (TV); gelgar@nimr.mrc.ac.uk (GE)

    Affiliation: Systems Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Published: November 21, 2013
  • DOI: 10.1371/journal.pgen.1003904

About the Authors

Laura Doglio, Stefan Pauls, Greg Elgar
Systems Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
Debbie K. Goode
Dept. of Haematology, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom
Maria C. Pelleri, Flavia Frabetti
Center for Research in Molecular Genetics Fondazione CARISBO, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
Sebastian M. Shimeld
Department of Zoology, University of Oxford, Oxford, United Kingdom
Tanya Vavouri
Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Badalona, Barcelona, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GE TV. Performed the experiments: LD TV MCP DKG SMS. Analyzed the data: GE TV SP MCP FF. Contributed reagents/materials/analysis tools: GE SMS. Wrote the paper: GE TV SMS SP.