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Research Article

Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans

  • Noa Safra mail,

    nsafra@ucdavis.edu

    Affiliation: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Alexander G. Bassuk,

    Affiliation: Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Polly J. Ferguson,

    Affiliation: Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Miriam Aguilar,

    Affiliation: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Rochelle L. Coulson,

    Affiliation: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California Davis, Davis, California, United States of America

    X
  • Nicholas Thomas,

    Affiliation: Department of Plant Pathology, University of California Davis, Davis, California, United States of America

    X
  • Peta L. Hitchens,

    Affiliation: JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Peter J. Dickinson,

    Affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Karen M. Vernau,

    Affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Zena T. Wolf,

    Affiliation: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Danika L. Bannasch

    Affiliation: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Published: July 18, 2013
  • DOI: 10.1371/journal.pgen.1003646

About the Authors

Noa Safra, Miriam Aguilar, Zena T. Wolf, Danika L. Bannasch
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
Alexander G. Bassuk, Polly J. Ferguson
Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America
Rochelle L. Coulson
Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California Davis, Davis, California, United States of America
Nicholas Thomas
Department of Plant Pathology, University of California Davis, Davis, California, United States of America
Peta L. Hitchens
JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
Peter J. Dickinson, Karen M. Vernau
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: nsafra@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS AGB DLB. Performed the experiments: NS MA RLC NT. Analyzed the data: NS AGB PLH PJD DLB. Contributed reagents/materials/analysis tools: PJF KMV ZTW. Wrote the paper: NS.