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Research Article

SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice

  • Xiangming Li,

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

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  • Joel D. Sanneman,

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

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  • Donald G. Harbidge,

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

    X
  • Fei Zhou,

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

    X
  • Taku Ito,

    Affiliation: Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

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  • Raoul Nelson,

    Affiliation: Department of Pediatrics, Division of Nephrology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America

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  • Nicolas Picard,

    Affiliation: Inserm, UMRS 970, Centre de recherche PARCC (Paris centre de recherche cardiovasculaire); Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, Paris, France

    X
  • Régine Chambrey,

    Affiliation: Inserm, UMRS 970, Centre de recherche PARCC (Paris centre de recherche cardiovasculaire); Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, Paris, France

    X
  • Dominique Eladari,

    Affiliations: Inserm, UMRS 970, Centre de recherche PARCC (Paris centre de recherche cardiovasculaire); Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, Paris, France, Département de Physiologie, HEGP, AP-HP, Paris, France

    X
  • Tracy Miesner,

    Affiliation: Comparative Medicine Group, Kansas State University, Manhattan, Kansas, United States of America

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  • Andrew J. Griffith,

    Affiliation: Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

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  • Daniel C. Marcus,

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

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  • Philine Wangemann mail

    wange@vet.ksu.edu

    Affiliation: Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America

    X
  • Published: July 11, 2013
  • DOI: 10.1371/journal.pgen.1003641

About the Authors

Xiangming Li, Joel D. Sanneman, Donald G. Harbidge, Fei Zhou, Daniel C. Marcus, Philine Wangemann
Anatomy & Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
Taku Ito, Andrew J. Griffith
Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America
Raoul Nelson
Department of Pediatrics, Division of Nephrology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
Nicolas Picard, Régine Chambrey, Dominique Eladari
Inserm, UMRS 970, Centre de recherche PARCC (Paris centre de recherche cardiovasculaire); Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, Paris, France
Dominique Eladari
Département de Physiologie, HEGP, AP-HP, Paris, France
Tracy Miesner
Comparative Medicine Group, Kansas State University, Manhattan, Kansas, United States of America

Corresponding Author

Email: wange@vet.ksu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PW DCM AJG. Performed the experiments: XL JDS DGH FZ PW. Analyzed the data: XL JDS DGH FZ PW. Contributed reagents/materials/analysis tools: PW RN NP RC DE TI AJG. Wrote the paper: XL PW. Mouse colony management and genotyping: TM.