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Research Article

Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits

  • Noah Zaitlen mail,

    noah.zaitlen@ucsf.edu (NZ); aprice@hsph.harvard.edu (ALP)

    Affiliation: Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, California, United States of America

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  • Peter Kraft,

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Nick Patterson,

    Affiliation: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Bogdan Pasaniuc,

    Affiliation: Interdepartmental Program in Bioinformatics Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Gaurav Bhatia,

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Samuela Pollack,

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Alkes L. Price mail

    noah.zaitlen@ucsf.edu (NZ); aprice@hsph.harvard.edu (ALP)

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: May 30, 2013
  • DOI: 10.1371/journal.pgen.1003520

About the Authors

Noah Zaitlen
Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, California, United States of America
Peter Kraft, Gaurav Bhatia, Samuela Pollack, Alkes L. Price
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Peter Kraft, Gaurav Bhatia, Samuela Pollack, Alkes L. Price
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Peter Kraft, Nick Patterson, Gaurav Bhatia, Samuela Pollack, Alkes L. Price
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Bogdan Pasaniuc
Interdepartmental Program in Bioinformatics Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NZ NP ALP. Performed the experiments: NZ SP. Analyzed the data: NZ PK NP BP GB ALP. Wrote the paper: NZ ALP.