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Research Article

Molecular Networks of Human Muscle Adaptation to Exercise and Age

  • Bethan E. Phillips,

    Affiliation: Graduate Entry Medicine and Health, Royal Derby Hospital, Derbyshire, United Kingdom

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  • John P. Williams,

    Affiliation: Graduate Entry Medicine and Health, Royal Derby Hospital, Derbyshire, United Kingdom

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  • Thomas Gustafsson,

    Affiliation: Karolinska Institutet, Stockholm, Sweden

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  • Claude Bouchard,

    Affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Tuomo Rankinen,

    Affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Steen Knudsen,

    Affiliation: Medical Prognosis Institute, Hørsholm, Denmark

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  • Kenneth Smith,

    Affiliation: Graduate Entry Medicine and Health, Royal Derby Hospital, Derbyshire, United Kingdom

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  • James A. Timmons equal contributor mail,

    equal contributor Contributed equally to this work with: James A. Timmons, Philip J. Atherton

    Jamie.Timmons@gmail.com

    Affiliations: XRgenomics Ltd., Leicestershire, United Kingdom, Loughborough University, Loughborough, United Kingdom

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  • Philip J. Atherton equal contributor

    equal contributor Contributed equally to this work with: James A. Timmons, Philip J. Atherton

    Affiliation: Graduate Entry Medicine and Health, Royal Derby Hospital, Derbyshire, United Kingdom

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  • Published: March 21, 2013
  • DOI: 10.1371/journal.pgen.1003389

About the Authors

Bethan E. Phillips, John P. Williams, Kenneth Smith, Philip J. Atherton
Graduate Entry Medicine and Health, Royal Derby Hospital, Derbyshire, United Kingdom
Thomas Gustafsson
Karolinska Institutet, Stockholm, Sweden
Claude Bouchard, Tuomo Rankinen
Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
Steen Knudsen
Medical Prognosis Institute, Hørsholm, Denmark
James A. Timmons
XRgenomics Ltd., Leicestershire, United Kingdom
James A. Timmons
Loughborough University, Loughborough, United Kingdom

Corresponding Author

Email: Jamie.Timmons@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KS PJA JAT CB TG. Performed the experiments: BEP JPW CB KS JAT PJA. Analyzed the data: BEP KS JAT PJA. Contributed reagents/materials/analysis tools: CB TR TG. Wrote the paper: BEP TG CB SK JAT PJA.