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Research Article

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

  • Yun Deng equal contributor,

    equal contributor Contributed equally to this work with: Yun Deng, Jian Zhao

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Jian Zhao equal contributor,

    equal contributor Contributed equally to this work with: Yun Deng, Jian Zhao

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Daisuke Sakurai,

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Kenneth M. Kaufman,

    Affiliations: Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

    X
  • Jeffrey C. Edberg,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Robert P. Kimberly,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Diane L. Kamen,

    Affiliation: Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Gary S. Gilkeson,

    Affiliation: Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Chaim O. Jacob,

    Affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • R. Hal Scofield,

    Affiliations: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, U.S. Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States of America

    X
  • Carl D. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America

    X
  • Jennifer A. Kelly,

    Affiliation: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Rosalind Ramsey-Goldman,

    Affiliation: Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • Michelle A. Petri,

    Affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • John D. Reveille,

    Affiliation: Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Luis M. Vilá,

    Affiliation: Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

    X
  • Graciela S. Alarcón,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Timothy J. Vyse,

    Affiliation: Divisions of Genetics and Molecular Medicine and Immunology, King's College London, London, United Kingdom

    X
  • Bernardo A. Pons-Estel,

    Affiliation: Department of Medicine, Sanatorio Parque, Rosario, Argentina

    X
  • on behalf of the Argentine Collaborative Group ,

    Memberships of the consortia are provided in the Acknowledgments.

    X
  • Barry I. Freedman,

    Affiliation: Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Patrick M. Gaffney,

    Affiliation: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Kathy Moser Sivils,

    Affiliation: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Judith A. James,

    Affiliations: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

    X
  • Peter K. Gregersen,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

    X
  • Juan-Manuel Anaya,

    Affiliation: Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia

    X
  • Timothy B. Niewold,

    Affiliation: Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Joan T. Merrill,

    Affiliation: Clinical Pharmacology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Lindsey A. Criswell,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Anne M. Stevens,

    Affiliations: Division of Rheumatology, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, United States of America

    X
  • Susan A. Boackle,

    Affiliation: Division of Rheumatology, School of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America

    X
  • Rita M. Cantor,

    Affiliation: Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Weiling Chen,

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Jeniffer M. Grossman,

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Bevra H. Hahn,

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • John B. Harley,

    Affiliations: Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

    X
  • Marta E. Alarcόn-Riquelme,

    Affiliations: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Centro de Genómica e Investigación Oncológica (GENYO), Pfizer–Universidad de Granada–Junta de Andalucia, Granada, Spain

    X
  • on behalf of the BIOLUPUS and GENLES networks ,

    Memberships of the consortia are provided in the Acknowledgments.

    X
  • Elizabeth E. Brown,

    Affiliations: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Betty P. Tsao mail

    btsao@mednet.ucla.edu

    Affiliation: Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003336

About the Authors

Yun Deng, Jian Zhao, Daisuke Sakurai, Weiling Chen, Jeniffer M. Grossman, Bevra H. Hahn, Betty P. Tsao
Division of Rheumatology, University of California Los Angeles, Los Angeles, California, United States of America
Kenneth M. Kaufman, John B. Harley
Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Kenneth M. Kaufman, John B. Harley
U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America
Jeffrey C. Edberg, Robert P. Kimberly, Graciela S. Alarcón, Elizabeth E. Brown
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Diane L. Kamen, Gary S. Gilkeson
Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, United States of America
Chaim O. Jacob
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
R. Hal Scofield, Jennifer A. Kelly, Patrick M. Gaffney, Kathy Moser Sivils, Judith A. James, Marta E. Alarcόn-Riquelme
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
R. Hal Scofield, Judith A. James
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
R. Hal Scofield
U.S. Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States of America
Carl D. Langefeld
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America
Rosalind Ramsey-Goldman
Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Michelle A. Petri
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
John D. Reveille
Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Luis M. Vilá
Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Timothy J. Vyse
Divisions of Genetics and Molecular Medicine and Immunology, King's College London, London, United Kingdom
Bernardo A. Pons-Estel
Department of Medicine, Sanatorio Parque, Rosario, Argentina
Barry I. Freedman
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Peter K. Gregersen
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America
Juan-Manuel Anaya
Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
Timothy B. Niewold
Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
Joan T. Merrill
Clinical Pharmacology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
Lindsey A. Criswell
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Anne M. Stevens
Division of Rheumatology, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
Anne M. Stevens
Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, United States of America
Susan A. Boackle
Division of Rheumatology, School of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
Rita M. Cantor
Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
Marta E. Alarcόn-Riquelme
Centro de Genómica e Investigación Oncológica (GENYO), Pfizer–Universidad de Granada–Junta de Andalucia, Granada, Spain
Elizabeth E. Brown
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Corresponding Author

Email: btsao@mednet.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BPT YD JZ. Performed the experiments: YD JZ WC. Analyzed the data: YD JZ DS KMK CDL JAK RMC. Contributed reagents/materials/analysis tools: BPT JCE RPK DLK GSG COJ RHS RR-G MAP JDR LMV GSA TJV BAP-E BIF PMG KMS JAJ PKG J-MA TBN JTM LAC AMS SAB JMG BHH JBH MEA-R EEB. Wrote the paper: YD. Revised the manuscript: JZ BPT JTM AMS SAB EEB.