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Research Article

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

  • Shanow Uthman equal contributor,

    equal contributor Contributed equally to this work with: Shanow Uthman, Christian Bär

    Affiliation: Department of Genetics, University of Leicester, Leicester, United Kingdom

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  • Christian Bär equal contributor,

    equal contributor Contributed equally to this work with: Shanow Uthman, Christian Bär

    Affiliations: Department of Genetics, University of Leicester, Leicester, United Kingdom, Institut für Biologie, FG Mikrobiologie, Universität Kassel, Kassel, Germany

    Current address: Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernandez Almagro 3, Madrid, Spain

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  • Viktor Scheidt,

    Affiliation: Institut für Biologie, FG Mikrobiologie, Universität Kassel, Kassel, Germany

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  • Shihui Liu,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sara ten Have,

    Affiliation: Centre for Gene Regulation and Expression, College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee, Scotland

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  • Flaviano Giorgini,

    Affiliation: Department of Genetics, University of Leicester, Leicester, United Kingdom

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  • Michael J. R. Stark mail,

    m.j.r.stark@dundee.ac.uk (MJRS); schaffrath@uni-kassel.de, rs240@le.ac.uk (RS)

    Affiliation: Centre for Gene Regulation and Expression, College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee, Scotland

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  • Raffael Schaffrath mail

    m.j.r.stark@dundee.ac.uk (MJRS); schaffrath@uni-kassel.de, rs240@le.ac.uk (RS)

    Affiliations: Department of Genetics, University of Leicester, Leicester, United Kingdom, Institut für Biologie, FG Mikrobiologie, Universität Kassel, Kassel, Germany

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003334

About the Authors

Shanow Uthman, Christian Bär, Flaviano Giorgini, Raffael Schaffrath
Department of Genetics, University of Leicester, Leicester, United Kingdom
Christian Bär, Viktor Scheidt, Raffael Schaffrath
Institut für Biologie, FG Mikrobiologie, Universität Kassel, Kassel, Germany
Shihui Liu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Sara ten Have, Michael J. R. Stark
Centre for Gene Regulation and Expression, College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee, Scotland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SU CB SL FG MJRS RS. Performed the experiments: SU CB VS SL StH. Analyzed the data: SU CB SL VS StH FG MJRS RS. Contributed reagents/materials/analysis tools: SU CB VS SL StH MJRS. Wrote the paper: FG MJRS RS.