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Research Article

Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases

  • Bahar Edrissi,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Koli Taghizadeh,

    Affiliation: Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Peter C. Dedon mail

    pcdedon@mit.edu

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003328

About the Authors

Bahar Edrissi, Peter C. Dedon
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Koli Taghizadeh, Peter C. Dedon
Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: pcdedon@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BE PCD. Performed the experiments: BE KT. Analyzed the data: BE KT PCD. Wrote the paper: BE KT PCD.