Advertisement
Research Article

Age-Dependent Transition from Cell-Level to Population-Level Control in Murine Intestinal Homeostasis Revealed by Coalescence Analysis

  • Zheng Hu,

    Affiliations: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, Graduate University of Chinese Academy of Sciences, Beijing, China

    X
  • Yun-Xin Fu,

    Affiliation: Human Genetics Center and Division of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Anthony J. Greenberg,

    Affiliation: Departments of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

    X
  • Chung-I Wu mail,

    weiweizhai@big.ac.cn (WZ); ciwu@uchicago.edu (C-IW)

    Affiliations: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

    X
  • Weiwei Zhai mail

    weiweizhai@big.ac.cn (WZ); ciwu@uchicago.edu (C-IW)

    Affiliations: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China

    X
  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003326

About the Authors

Zheng Hu, Chung-I Wu, Weiwei Zhai
Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Zheng Hu
Graduate University of Chinese Academy of Sciences, Beijing, China
Yun-Xin Fu
Human Genetics Center and Division of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Anthony J. Greenberg
Departments of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
Chung-I Wu
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
Weiwei Zhai
National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WZ ZH. Performed the experiments: ZH Y-XF C-IW WZ. Analyzed the data: ZH Y-XF C-IW WZ. Wrote the paper: ZH Y-XF AJG C-IW WZ.