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Research Article

Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2

  • Wei Shi equal contributor,

    equal contributor Contributed equally to this work with: Wei Shi, Amanda L. Bain

    Affiliation: Queensland Institute of Medical Research, Herston, Australia

    X
  • Amanda L. Bain equal contributor,

    equal contributor Contributed equally to this work with: Wei Shi, Amanda L. Bain

    Affiliations: Queensland Institute of Medical Research, Herston, Australia, School of Biomolecular and Physical Sciences, Griffith University, Nathan, Australia

    X
  • Bjoern Schwer,

    Affiliations: Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Genetics and Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Fares Al-Ejeh,

    Affiliation: Queensland Institute of Medical Research, Herston, Australia

    X
  • Corey Smith,

    Affiliation: Queensland Institute of Medical Research, Herston, Australia

    X
  • Lee Wong,

    Affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia

    X
  • Hua Chai,

    Affiliations: Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Genetics and Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Mariska S. Miranda,

    Affiliations: Queensland Institute of Medical Research, Herston, Australia, School of Medicine, University of Queensland, Herston, Australia

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  • Uda Ho,

    Affiliation: Queensland Institute of Medical Research, Herston, Australia

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  • Makoto Kawaguchi,

    Affiliation: Department of Bioregulation and Molecular Neurobiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan

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  • Yutaka Miura,

    Affiliation: Department of Bioregulation and Molecular Neurobiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan

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  • John W. Finnie,

    Affiliation: SA Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia

    X
  • Meaghan Wall,

    Affiliations: Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Fitzroy, Melbourne, Australia, Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia

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  • Jörg Heierhorst,

    Affiliations: Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia, St. Vincent's Institute, Fitzroy, Australia

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  • Carol Wicking,

    Affiliation: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Australia

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  • Kevin J. Spring,

    Affiliations: Queensland Institute of Medical Research, Herston, Australia, School of Biomolecular and Physical Sciences, Griffith University, Nathan, Australia, School of Medicine, University of Queensland, Herston, Australia

    X
  • Frederick W. Alt,

    Affiliations: Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Genetics and Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Kum Kum Khanna mail

    kumkum.khanna@qimr.edu.au

    Affiliations: Queensland Institute of Medical Research, Herston, Australia, School of Biomolecular and Physical Sciences, Griffith University, Nathan, Australia, School of Medicine, University of Queensland, Herston, Australia

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.pgen.1003298

About the Authors

Wei Shi, Amanda L. Bain, Fares Al-Ejeh, Corey Smith, Mariska S. Miranda, Uda Ho, Kevin J. Spring, Kum Kum Khanna
Queensland Institute of Medical Research, Herston, Australia
Amanda L. Bain, Kevin J. Spring, Kum Kum Khanna
School of Biomolecular and Physical Sciences, Griffith University, Nathan, Australia
Bjoern Schwer, Hua Chai, Frederick W. Alt
Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America
Bjoern Schwer, Hua Chai, Frederick W. Alt
Department of Genetics and Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
Lee Wong
Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia
Mariska S. Miranda, Kevin J. Spring, Kum Kum Khanna
School of Medicine, University of Queensland, Herston, Australia
Makoto Kawaguchi, Yutaka Miura
Department of Bioregulation and Molecular Neurobiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
John W. Finnie
SA Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
Meaghan Wall
Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Fitzroy, Melbourne, Australia
Meaghan Wall, Jörg Heierhorst
Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia
Jörg Heierhorst
St. Vincent's Institute, Fitzroy, Australia
Carol Wicking
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Australia

Corresponding Author

Email: kumkum.khanna@qimr.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WS ALB BS FA-E CS LW HC UH MK YM MW JH CW KJS FWA KKK. Performed the experiments: WS ALB BS FA-E CS LW HC MSM MK MW. Analyzed the data: WS ALB BS FA-E HC MK YM JWF MW JH CW KJS FWA KKK. Contributed reagents/materials/analysis tools: ALB WS BS. Wrote the paper: WS ALB BS FWA KKK.