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Research Article

An Evolutionary Perspective on Epistasis and the Missing Heritability

  • Gibran Hemani mail,

    g.hemani@uq.edu.au

    Affiliation: The Roslin Institute and Royal (Dick) School of Veterinary Science, University of Edinburgh, Edinburgh, United Kingdom

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  • Sara Knott,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Chris Haley

    Affiliations: The Roslin Institute and Royal (Dick) School of Veterinary Science, University of Edinburgh, Edinburgh, United Kingdom, Institute for Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003295

About the Authors

Gibran Hemani, Chris Haley
The Roslin Institute and Royal (Dick) School of Veterinary Science, University of Edinburgh, Edinburgh, United Kingdom
Sara Knott
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
Chris Haley
Institute for Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

Corresponding Author

Email: g.hemani@uq.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GH SK CH. Performed the experiments: GH. Analyzed the data: GH. Wrote the paper: GH.