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Research Article

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

  • Michael A. Lodato,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Christopher W. Ng equal contributor,

    equal contributor Contributed equally to this work with: Christopher W. Ng, Joseph A. Wamstad

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Joseph A. Wamstad equal contributor,

    equal contributor Contributed equally to this work with: Christopher W. Ng, Joseph A. Wamstad

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Albert W. Cheng,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kevin K. Thai,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Ernest Fraenkel,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Rudolf Jaenisch mail,

    jaenisch@wi.mit.edu (RJ); lboyer@mit.edu (LAB)

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Laurie A. Boyer mail

    jaenisch@wi.mit.edu (RJ); lboyer@mit.edu (LAB)

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: February 21, 2013
  • DOI: 10.1371/journal.pgen.1003288

About the Authors

Michael A. Lodato, Joseph A. Wamstad, Albert W. Cheng, Kevin K. Thai, Rudolf Jaenisch, Laurie A. Boyer
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Michael A. Lodato, Albert W. Cheng, Rudolf Jaenisch
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Christopher W. Ng, Ernest Fraenkel
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Albert W. Cheng
Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL RJ LAB. Performed the experiments: MAL CWN JAW AWC KKT. Analyzed the data: MAL CWN JAW AWC. Contributed reagents/materials/analysis tools: AWC EF. Wrote the paper: MAL LAB.