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Research Article

Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

  • Marie-Jo Halaby,

    Affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

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  • Anne Hakem,

    Affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

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  • Li Li,

    Affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

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  • Samah El Ghamrasni,

    Affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

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  • Shriram Venkatesan,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine and Tembusu College, National University of Singapore, Singapore, Singapore

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  • Prakash M. Hande,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine and Tembusu College, National University of Singapore, Singapore, Singapore

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  • Otto Sanchez,

    Affiliation: University of Ontario Institute of Technology, Oshawa, Ontario, Canada

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  • Razqallah Hakem mail

    rhakem@uhnres.utoronto.ca

    Affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada

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  • Published: January 31, 2013
  • DOI: 10.1371/journal.pgen.1003259

About the Authors

Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Razqallah Hakem
Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
Shriram Venkatesan, Prakash M. Hande
Department of Physiology, Yong Loo Lin School of Medicine and Tembusu College, National University of Singapore, Singapore, Singapore
Otto Sanchez
University of Ontario Institute of Technology, Oshawa, Ontario, Canada

Corresponding Author

Email: rhakem@uhnres.utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M-JH RH. Performed the experiments: M-JH AH LL SEG SV. Analyzed the data: M-JH AH LL PMH OS RH. Wrote the paper: M-JH RH.