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Research Article

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

  • Renee D. Read mail,

    renee.read@emory.edu

    Affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

    Current address: Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Tim R. Fenton,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • German G. Gomez,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Jill Wykosky,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Scott R. Vandenberg,

    Affiliation: Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Ivan Babic,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Akio Iwanami,

    Affiliation: Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

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  • Huijun Yang,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Webster K. Cavenee,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California, United States of America

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  • Paul S. Mischel,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Frank B. Furnari,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • John B. Thomas

    Affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Published: February 14, 2013
  • DOI: 10.1371/journal.pgen.1003253

About the Authors

Renee D. Read, John B. Thomas
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America
Tim R. Fenton, German G. Gomez, Jill Wykosky, Ivan Babic, Huijun Yang, Webster K. Cavenee, Paul S. Mischel, Frank B. Furnari
Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America
Scott R. Vandenberg, Paul S. Mischel, Frank B. Furnari
Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America
Akio Iwanami
Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
Webster K. Cavenee
Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California, United States of America

Corresponding Author

Email: renee.read@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RDR TRF JBT WKC FBF. Performed the experiments: RDR TRF GGG JW AI HY. Analyzed the data: RDR TRF JBT FBF WKC GGG JW SRV. Contributed reagents/materials/analysis tools: GGG IB PSM. Wrote the paper: RDR TRF. Edited the manuscript: RDR JBT WKC FBF.