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Research Article

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

  • B. R. Achyut,

    Affiliation: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • David A. Bader,

    Affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ana I. Robles,

    Affiliation: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Darawalee Wangsa,

    Affiliation: Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Curtis C. Harris,

    Affiliation: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Thomas Ried,

    Affiliation: Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Li Yang mail

    yangl3@mail.nih.gov

    Affiliation: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.pgen.1003251

About the Authors

B. R. Achyut, Li Yang
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
David A. Bader
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Ana I. Robles, Curtis C. Harris
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Darawalee Wangsa, Thomas Ried
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: yangl3@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BRA AIR CCH TR LY. Performed the experiments: BRA DAB AIR DW. Analyzed the data: BRA AIR CCH TR LY. Contributed reagents/materials/analysis tools: BRA AIR CCH TR LY. Wrote the paper: BRA LY.