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Research Article

Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure

  • Lavinia Paternoster equal contributor,

    equal contributor Contributed equally to this work with: Lavinia Paternoster, Mattias Lorentzon, Terho Lehtimäki, Joel Eriksson

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Mattias Lorentzon equal contributor,

    equal contributor Contributed equally to this work with: Lavinia Paternoster, Mattias Lorentzon, Terho Lehtimäki, Joel Eriksson

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Terho Lehtimäki equal contributor,

    equal contributor Contributed equally to this work with: Lavinia Paternoster, Mattias Lorentzon, Terho Lehtimäki, Joel Eriksson

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Joel Eriksson equal contributor,

    equal contributor Contributed equally to this work with: Lavinia Paternoster, Mattias Lorentzon, Terho Lehtimäki, Joel Eriksson

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    X
  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Olli Raitakari,

    Affiliations: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

    X
  • Marika Laaksonen,

    Affiliation: Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland

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  • Harri Sievänen,

    Affiliation: The UKK Institute for Health Promotion Research, Tampere, Finland

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  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

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  • Leo-Pekka Lyytikäinen,

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Dan Mellström,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Magnus Karlsson,

    Affiliation: Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics, Lund University, Skane University Hospital, Malmö, Sweden

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  • Östen Ljunggren,

    Affiliation: Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden

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  • Elin Grundberg,

    Affiliations: Department of Human Genetics, McGill University, Montreal, Canada, McGill University and Genome Quebec Innovation Centre, Montreal, Canada

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  • John P. Kemp,

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Adrian Sayers,

    Affiliations: School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom

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  • Maria Nethander,

    Affiliation: Genomics Core Facility, University of Gothenburg, Gothenburg, Sweden

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  • David M. Evans ,

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

    These authors also contributed equally to this work.

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  • Liesbeth Vandenput ,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    These authors also contributed equally to this work.

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  • Jon H. Tobias ,

    Affiliation: School of Clinical Sciences, University of Bristol, Bristol, United Kingdom

    These authors also contributed equally to this work.

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  • Claes Ohlsson mail

    claes.ohlsson@medic.gu.se

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    These authors also contributed equally to this work.

    X
  • Published: February 21, 2013
  • DOI: 10.1371/journal.pgen.1003247

About the Authors

Lavinia Paternoster, John P. Kemp, David M. Evans
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
Lavinia Paternoster, John P. Kemp, Adrian Sayers, David M. Evans
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Mattias Lorentzon, Joel Eriksson, Dan Mellström, Liesbeth Vandenput, Claes Ohlsson
Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Terho Lehtimäki, Leo-Pekka Lyytikäinen
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland
Mika Kähönen
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
Olli Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Olli Raitakari
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
Marika Laaksonen
Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
Harri Sievänen
The UKK Institute for Health Promotion Research, Tampere, Finland
Jorma Viikari
Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
Magnus Karlsson
Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics, Lund University, Skane University Hospital, Malmö, Sweden
Östen Ljunggren
Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
Elin Grundberg
Department of Human Genetics, McGill University, Montreal, Canada
Elin Grundberg
McGill University and Genome Quebec Innovation Centre, Montreal, Canada
Adrian Sayers, Jon H. Tobias
School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
Maria Nethander
Genomics Core Facility, University of Gothenburg, Gothenburg, Sweden

Corresponding Author

Email: claes.ohlsson@medic.gu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: L Paternoster, M Lorentzon, T Lehtimäki, M Kähönen, M Laaksonen, H Sievänen, J Viikari, D Mellström, E Grundberg, M Karlsson, DM Evans, L Vandenput, JH Tobias, C Ohlsson. Performed the experiments: L Paternoster, E Grundberg, M Lorentzon, T Lehtimäki, M Kähönen, O Raitakari, J Viikari, M Laaksonen, L Vandenput, C Ohlsson. Analyzed the data: L Paternoster, T Lehtimäki, J Eriksson, L-P Lyytikäinen, JP Kemp, A Sayers, M Nethander, C Ohlsson. Contributed reagents/materials/analysis tools: M Lorentzon, T Lehtimäki, J Eriksson, O Raitakari, E Grundberg, Ö Ljunggren, M Laaksonen, H Sievänen, J Viikari, L-P Lyytikäinen, D Mellström, M Karlsson, JP Kemp, DM Evans, JH Tobias, C Ohlsson. Wrote the paper: L Paternoster, DM Evans, L Vandeput, JH Tobias, C Ohlsson.