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Research Article

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

  • Colin D. Meiklejohn,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

    Current address: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • Marissa A. Holmbeck,

    Affiliation: Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Mohammad A. Siddiq,

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

    Current address: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

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  • Dawn N. Abt,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

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  • David M. Rand,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

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  • Kristi L. Montooth

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • Published: January 31, 2013
  • DOI: 10.1371/journal.pgen.1003238

About the Authors

Colin D. Meiklejohn, Dawn N. Abt, David M. Rand
Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
Marissa A. Holmbeck
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America
Mohammad A. Siddiq, Kristi L. Montooth
Department of Biology, Indiana University, Bloomington, Indiana, United States of America

Corresponding Author

Email: montooth@indiana.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CDM DMR KLM. Performed the experiments: CDM MAH MAS DNA DMR KLM. Analyzed the data: CDM MAH DMR KLM. Wrote the paper: KLM.