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Research Article

Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds

  • Jessica L. Petersen mail,

    jlpeters@umn.edu

    Affiliation: College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

    X
  • James R. Mickelson,

    Affiliation: College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

    X
  • Aaron K. Rendahl,

    Affiliation: School of Statistics, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Stephanie J. Valberg,

    Affiliation: College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

    X
  • Lisa S. Andersson,

    Affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

    X
  • Jeanette Axelsson,

    Affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

    X
  • Ernie Bailey,

    Affiliation: Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, United States of America

    X
  • Danika Bannasch,

    Affiliation: School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Matthew M. Binns,

    Affiliation: Equine Analysis, Midway, Kentucky, United States of America

    X
  • Alexandre S. Borges,

    Affiliation: Department of Veterinary Clinical Science, University Estadual Paulista, Botucatu, Brazil

    X
  • Pieter Brama,

    Affiliation: School of Veterinary Medicine, University College Dublin, Dublin, Ireland

    X
  • Artur da Câmara Machado,

    Affiliation: Department of Agriculture, University of the Azores, Angra do Heroísmo, Portugal

    X
  • Stefano Capomaccio,

    Affiliation: Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy

    X
  • Katia Cappelli,

    Affiliation: Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy

    X
  • E. Gus Cothran,

    Affiliation: College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, Texas, United States of America

    X
  • Ottmar Distl,

    Affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany

    X
  • Laura Fox-Clipsham,

    Affiliation: Animal Health Trust, Lanwades Park, Newmarket, Suffolk, United Kingdom

    X
  • Kathryn T. Graves,

    Affiliation: Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, United States of America

    X
  • Gérard Guérin,

    Affiliation: Animal Genetics and Integrative Biology Unit, French National Institute for Agricultural Research, Jouy en Josas, France

    X
  • Bianca Haase,

    Affiliation: Faculty of Veterinary Science, University of Sydney, New South Wales, Australia

    X
  • Telhisa Hasegawa,

    Affiliation: Nihon Bioresource College, Koga, Ibaraki, Japan

    X
  • Karin Hemmann,

    Affiliation: Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

    X
  • Emmeline W. Hill,

    Affiliation: College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland

    X
  • Tosso Leeb,

    Affiliation: Institute of Genetics, University of Bern, Bern, Switzerland

    X
  • Gabriella Lindgren,

    Affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

    X
  • Hannes Lohi,

    Affiliation: Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

    X
  • Maria Susana Lopes,

    Affiliation: Department of Agriculture, University of the Azores, Angra do Heroísmo, Portugal

    X
  • Beatrice A. McGivney,

    Affiliation: College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland

    X
  • Sofia Mikko,

    Affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

    X
  • Nicholas Orr,

    Affiliation: Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom

    X
  • M. Cecilia T. Penedo,

    Affiliation: School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Richard J. Piercy,

    Affiliation: Comparative Neuromuscular Diseases Laboratory, Royal Veterinary College, London, United Kingdom

    X
  • Marja Raekallio,

    Affiliation: Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland

    X
  • Stefan Rieder,

    Affiliation: Swiss National Stud Farm SNSTF, Agroscope Liebefeld-Posieux Research Station, Avenches, Switzerland

    X
  • Knut H. Røed,

    Affiliation: Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • June Swinburne,

    Affiliations: Animal Health Trust, Lanwades Park, Newmarket, Suffolk, United Kingdom, Animal DNA Diagnostics, Cambridge, United Kingdom

    X
  • Teruaki Tozaki,

    Affiliation: Department of Molecular Genetics, Laboratory of Racing Chemistry, Utsunomiya, Tochigi, Japan

    X
  • Mark Vaudin,

    Affiliation: Animal Health Trust, Lanwades Park, Newmarket, Suffolk, United Kingdom

    X
  • Claire M. Wade,

    Affiliation: Faculty of Veterinary Science, University of Sydney, New South Wales, Australia

    X
  • Molly E. McCue

    Affiliation: College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pgen.1003211

About the Authors

Jessica L. Petersen, James R. Mickelson, Stephanie J. Valberg, Molly E. McCue
College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America
Aaron K. Rendahl
School of Statistics, University of Minnesota, Minneapolis, Minnesota, United States of America
Lisa S. Andersson, Jeanette Axelsson, Gabriella Lindgren, Sofia Mikko
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Ernie Bailey, Kathryn T. Graves
Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, United States of America
Danika Bannasch, M. Cecilia T. Penedo
School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
Matthew M. Binns
Equine Analysis, Midway, Kentucky, United States of America
Alexandre S. Borges
Department of Veterinary Clinical Science, University Estadual Paulista, Botucatu, Brazil
Pieter Brama
School of Veterinary Medicine, University College Dublin, Dublin, Ireland
Artur da Câmara Machado, Maria Susana Lopes
Department of Agriculture, University of the Azores, Angra do Heroísmo, Portugal
Stefano Capomaccio, Katia Cappelli
Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy
E. Gus Cothran
College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, Texas, United States of America
Ottmar Distl
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
Laura Fox-Clipsham, June Swinburne, Mark Vaudin
Animal Health Trust, Lanwades Park, Newmarket, Suffolk, United Kingdom
Gérard Guérin
Animal Genetics and Integrative Biology Unit, French National Institute for Agricultural Research, Jouy en Josas, France
Bianca Haase, Claire M. Wade
Faculty of Veterinary Science, University of Sydney, New South Wales, Australia
Telhisa Hasegawa
Nihon Bioresource College, Koga, Ibaraki, Japan
Karin Hemmann, Hannes Lohi, Marja Raekallio
Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
Emmeline W. Hill, Beatrice A. McGivney
College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
Tosso Leeb
Institute of Genetics, University of Bern, Bern, Switzerland
Nicholas Orr
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
Richard J. Piercy
Comparative Neuromuscular Diseases Laboratory, Royal Veterinary College, London, United Kingdom
Stefan Rieder
Swiss National Stud Farm SNSTF, Agroscope Liebefeld-Posieux Research Station, Avenches, Switzerland
Knut H. Røed
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
June Swinburne
Animal DNA Diagnostics, Cambridge, United Kingdom
Teruaki Tozaki
Department of Molecular Genetics, Laboratory of Racing Chemistry, Utsunomiya, Tochigi, Japan

Corresponding Author

Email: jlpeters@umn.edu

Competing Interests

Equinome Ltd. (EWH, Director) has been granted a license for commercial use of MSTN data as contained within patent applications: U.S. Provisional Serial Number 61/136553; Irish Patent Application Numbers 2008/0735 and 2010/0151; and Patent Cooperation Treaty number PCT/IE2009/000062. The PCT publication WO2010/029527A published 18 March 2010. Title: “A method for predicting athletics performance potential” and U.S. publication US2011/0262915 published 27 October 2011. Title: “Method for predicting the athletic performance potential of a subject.” EWH, NO, and BAM are named on the applications. MMB works for The Genetic Edge, previously published a paper on the association between SNPs in the MSTN region and best racing distance for elite Thoroughbred horses [46], and uses these markers in commercial tests. LSA and GL are co-applicants on a patent application concerning the commercial utilization of the DMRT3 mutation. These commercial ventures had no influence on the interpretation of the results relating to myostatin or gait presented in the paper.

Author Contributions

Conceived and designed the experiments: JLP JRM SJV MEM. Performed the experiments: JLP AKR SJV MEM. Analyzed the data: JLP AKR MEM. Contributed reagents/materials/analysis tools: JLP JRM AKR SJV LSA JA EB DB MMB ASB PB AdCM SC KC EGC OD LF-C KTG GG BH TH KH EWH TL GL HL MSL BAM SM NO MCTP RJP MR SR KHR JS TT MV CMW MEM. Wrote the paper: JLP JRM MEM.