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Research Article

Ectopic Expression of Ptf1a Induces Spinal Defects, Urogenital Defects, and Anorectal Malformations in Danforth's Short Tail Mice

  • Kei Semba equal contributor,

    equal contributor Contributed equally to this work with: Kei Semba, Kimi Araki

    Affiliations: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan, Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    X
  • Kimi Araki equal contributor,

    equal contributor Contributed equally to this work with: Kei Semba, Kimi Araki

    Affiliation: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

    X
  • Ken-ichirou Matsumoto,

    Affiliations: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan, Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    X
  • Hiroko Suda,

    Affiliations: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan, Department of Transplantation/Pediatric Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    X
  • Takashi Ando,

    Affiliations: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan, Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    X
  • Akira Sei,

    Affiliation: Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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  • Hiroshi Mizuta,

    Affiliation: Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    X
  • Katsumasa Takagi,

    Affiliation: Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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  • Mai Nakahara,

    Affiliation: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

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  • Mayumi Muta,

    Affiliation: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

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  • Gen Yamada,

    Affiliation: Department of Organ Formation, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

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  • Naomi Nakagata,

    Affiliation: Division of Reproductive Engineering, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

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  • Aritoshi Iida,

    Affiliation: Laboratory for Bone and Joint Diseases, RIKEN Center for Genomic Medicine, Tokyo, Japan

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  • Shiro Ikegawa,

    Affiliation: Laboratory for Bone and Joint Diseases, RIKEN Center for Genomic Medicine, Tokyo, Japan

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  • Yusuke Nakamura,

    Affiliation: Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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  • Masatake Araki,

    Affiliation: Division of Bioinformatics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

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  • Kuniya Abe,

    Affiliation: Technology Development Team for Mammalian Cellular Dynamics, BioResource Center, RIKEN, Tsukuba, Ibaraki, Japan

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  • Ken-ichi Yamamura mail

    yamamura@gpo.kumamoto-u.ac.jp

    Affiliation: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

    X
  • Published: February 21, 2013
  • DOI: 10.1371/journal.pgen.1003204

About the Authors

Kei Semba, Kimi Araki, Ken-ichirou Matsumoto, Hiroko Suda, Takashi Ando, Mai Nakahara, Mayumi Muta, Ken-ichi Yamamura
Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan
Kei Semba, Ken-ichirou Matsumoto, Takashi Ando, Akira Sei, Hiroshi Mizuta, Katsumasa Takagi
Department of Orthopedic and Neuro-Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Hiroko Suda
Department of Transplantation/Pediatric Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Gen Yamada
Department of Organ Formation, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan
Naomi Nakagata
Division of Reproductive Engineering, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan
Aritoshi Iida, Shiro Ikegawa
Laboratory for Bone and Joint Diseases, RIKEN Center for Genomic Medicine, Tokyo, Japan
Yusuke Nakamura
Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Masatake Araki
Division of Bioinformatics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan
Kuniya Abe
Technology Development Team for Mammalian Cellular Dynamics, BioResource Center, RIKEN, Tsukuba, Ibaraki, Japan

Corresponding Author

Email: yamamura@gpo.kumamoto-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Semba, K Araki, M Araki, K Abe, K Yamamura. Performed the experiments: K Semba, K Araki, K Matsumoto, H Suda, T Ando, M Nakahara, M Muta, A Iida, K Abe. Analyzed the data: K Semba, K Araki, A Sei, H Mizuta, K Takagi, G Yamada, A Iida, S Ikegawa, Y Nakamura, K Abe, K Yamamura. Contributed reagents/materials/analysis tools: K Semba, K Araki, N Nakagata, A Iida, Y Nakamura, K Abe. Wrote the paper: K Semba, K Yamamura.