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Research Article

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

  • Vinod Kumar,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Harm-Jan Westra equal contributor,

    equal contributor Contributed equally to this work with: Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Juha Karjalainen equal contributor,

    equal contributor Contributed equally to this work with: Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Daria V. Zhernakova equal contributor,

    equal contributor Contributed equally to this work with: Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Tõnu Esko,

    Affiliation: Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia

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  • Barbara Hrdlickova,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Rodrigo Almeida,

    Affiliations: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Graduate Program in Health Sciences, University of Brasilia School of Health Sciences, Brasilia, Brazil

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  • Alexandra Zhernakova,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Eva Reinmaa,

    Affiliation: Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia

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  • Urmo Võsa,

    Affiliation: Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia

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  • Marten H. Hofker,

    Affiliation: Molecular Genetics Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Rudolf S. N. Fehrmann,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Jingyuan Fu,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Sebo Withoff,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Andres Metspalu,

    Affiliation: Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia

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  • Lude Franke ,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    These authors were joint senior authors on this work.

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  • Cisca Wijmenga mail

    c.wijmenga@umcg.nl

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    These authors were joint senior authors on this work.

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pgen.1003201

About the Authors

Vinod Kumar, Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova, Barbara Hrdlickova, Rodrigo Almeida, Alexandra Zhernakova, Rudolf S. N. Fehrmann, Jingyuan Fu, Sebo Withoff, Lude Franke, Cisca Wijmenga
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Tõnu Esko, Eva Reinmaa, Urmo Võsa, Andres Metspalu
Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia
Rodrigo Almeida
Graduate Program in Health Sciences, University of Brasilia School of Health Sciences, Brasilia, Brazil
Marten H. Hofker
Molecular Genetics Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Corresponding Author

Email: c.wijmenga@umcg.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VK LF CW. Performed the experiments: VK H-JW JK DVZ TE BH RA AZ ER UV JF. Analyzed the data: VK H-JW JK DVZ. Contributed reagents/materials/analysis tools: MHH RSNF AM CW. Wrote the paper: VK H-JW SW LF CW.