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Research Article

Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination

  • Kenneth J. Finn,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Joachim J. Li mail

    Joachim.Li@ucsf.edu

    Affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pgen.1003192

About the Authors

Kenneth J. Finn
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Joachim J. Li
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: Joachim.Li@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJF JJL. Performed the experiments: KJF. Analyzed the data: KJF. Wrote the paper: KJF JJL.