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Research Article

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences

  • Vydianathan Ravi equal contributor,

    equal contributor Contributed equally to this work with: Vydianathan Ravi, Shipra Bhatia

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore

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  • Shipra Bhatia equal contributor,

    equal contributor Contributed equally to this work with: Vydianathan Ravi, Shipra Bhatia

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Philippe Gautier,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Felix Loosli,

    Affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

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  • Boon-Hui Tay,

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore

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  • Alice Tay,

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore

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  • Emma Murdoch,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Pedro Coutinho,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Veronica van Heyningen,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Sydney Brenner,

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore

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  • Byrappa Venkatesh mail,

    Dirk-Jan.Kleinjan@igmm.ed.ac.uk (DA Kleinjan); mcbbv@imcb.a-star.edu.sg (B Venkatesh)

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore

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  • Dirk A. Kleinjan mail

    Dirk-Jan.Kleinjan@igmm.ed.ac.uk (DA Kleinjan); mcbbv@imcb.a-star.edu.sg (B Venkatesh)

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.pgen.1003177

About the Authors

Vydianathan Ravi, Boon-Hui Tay, Alice Tay, Sydney Brenner, Byrappa Venkatesh
Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Biopolis, Singapore, Singapore
Shipra Bhatia, Philippe Gautier, Emma Murdoch, Pedro Coutinho, Veronica van Heyningen, Dirk A. Kleinjan
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Felix Loosli
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DA Kleinjan, B Venkatesh. Performed the experiments: S Bhatia, V Ravi, P Gautier, F Loosli, B-H Tay, A Tay, E Murdoch, P Coutinho, DA Kleinjan. Analyzed the data: DA Kleinjan, B Venkatesh, S Bhatia, V Ravi, P Gautier, V van Heyningen, S Brenner. Wrote the paper: DA Kleinjan, B Venkatesh.