Advertisement
Research Article

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

  • Ulrike Peters mail,

    upeters@fhcrc.org

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Kari E. North,

    Affiliations: Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Praveen Sethupathy,

    Affiliations: Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Steve Buyske,

    Affiliations: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America, Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Jeff Haessler,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Shuo Jiao,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Megan D. Fesinmeyer,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Rebecca D. Jackson,

    Affiliation: Department of Internal Medicine, Ohio State Medical Center, Columbus, Ohio, United States of America

    X
  • Lew H. Kuller,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Aleksandar Rajkovic,

    Affiliation: Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Unhee Lim,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

    X
  • Iona Cheng,

    Affiliation: Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Fred Schumacher,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Lynne Wilkens,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

    X
  • Rongling Li,

    Affiliation: Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Keri Monda,

    Affiliations: Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Georg Ehret,

    Affiliations: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Division of Cardiology, Geneva University Hospital, Geneva, Switzerland

    X
  • Khanh-Dung H. Nguyen,

    Affiliation: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Richard Cooper,

    Affiliation: Preventive Medicine and Epidemiology, Loyola University, Chicago, Illinois, United States of America

    X
  • Cora E. Lewis,

    Affiliation: Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America

    X
  • Mark Leppert,

    Affiliation: Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Marguerite R. Irvin,

    Affiliation: Department of Biostatistics, University of Alabama, Birmingham, Alabama, United States of America

    X
  • C. Charles Gu,

    Affiliation: Department of Biostatistics, Washington University, St. Louis, Missouri, United States of America

    X
  • Denise Houston,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Petra Buzkova,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Marylyn Ritchie,

    Affiliation: Pennsylvania State University, State College, Pennsylvania, United States of America

    X
  • Tara C. Matise,

    Affiliation: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Loic Le Marchand,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

    X
  • Lucia A. Hindorff,

    Affiliation: Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Dana C. Crawford,

    Affiliations: Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Charles Kooperberg

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pgen.1003171

About the Authors

Ulrike Peters, Jeff Haessler, Shuo Jiao, Megan D. Fesinmeyer, Charles Kooperberg
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Kari E. North, Praveen Sethupathy, Keri Monda
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Kari E. North, Keri Monda
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Praveen Sethupathy
Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Steve Buyske, Tara C. Matise
Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
Steve Buyske
Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America
Rebecca D. Jackson
Department of Internal Medicine, Ohio State Medical Center, Columbus, Ohio, United States of America
Lew H. Kuller
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Aleksandar Rajkovic, Iona Cheng
Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Unhee Lim, Lynne Wilkens, Loic Le Marchand
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
Fred Schumacher, Christopher A. Haiman
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
Rongling Li, Lucia A. Hindorff
Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Georg Ehret, Khanh-Dung H. Nguyen
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Georg Ehret
Division of Cardiology, Geneva University Hospital, Geneva, Switzerland
Richard Cooper
Preventive Medicine and Epidemiology, Loyola University, Chicago, Illinois, United States of America
Cora E. Lewis
Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America
Mark Leppert
Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
Marguerite R. Irvin
Department of Biostatistics, University of Alabama, Birmingham, Alabama, United States of America
C. Charles Gu
Department of Biostatistics, Washington University, St. Louis, Missouri, United States of America
Denise Houston
Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Petra Buzkova
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Marylyn Ritchie
Pennsylvania State University, State College, Pennsylvania, United States of America
Dana C. Crawford
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Dana C. Crawford
Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Author

Email: upeters@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: UP KEN SB RDJ LLM LAH DCC CAH CK. Performed the experiments: UP KEN PS SB SJ MDF RDJ UL IC FS LW RL KM GE K-DHN RC CEL ML MRI CCG DH PB MR TCM LLM LAH DCC CAH CK. Analyzed the data: UP KEN PS SB JH SJ FS CK. Contributed reagents/materials/analysis tools: RDJ LHK AR GE K-DHN RC CEL ML MRI CCG DH LLM DCC CAH CK. Wrote the paper: UP KEN PS GE LAH CAH CK.