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Research Article

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

  • Fiona McMurray equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Chris D. Church equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Rachel Larder equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • George Nicholson equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliations: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

    X
  • Sara Wells,

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Lydia Teboul,

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Y. C. Loraine Tung,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Debra Rimmington,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Fatima Bosch,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Veronica Jimenez,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Giles S. H. Yeo,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Stephen O'Rahilly,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Frances M. Ashcroft ,

    Affiliation: Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

    X
  • Anthony P. Coll ,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    These authors also contributed equally to this work.

    X
  • Roger D. Cox mail

    r.cox@har.mrc.ac.uk

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    These authors also contributed equally to this work.

    X
  • Published: January 03, 2013
  • DOI: 10.1371/journal.pgen.1003166

About the Authors

Fiona McMurray, Chris D. Church, George Nicholson, Sara Wells, Lydia Teboul, Roger D. Cox
MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom
Rachel Larder, Y. C. Loraine Tung, Debra Rimmington, Giles S. H. Yeo, Stephen O'Rahilly, Anthony P. Coll
University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
George Nicholson
Department of Statistics, University of Oxford, Oxford, United Kingdom
Fatima Bosch, Veronica Jimenez
Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
Fatima Bosch, Veronica Jimenez
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
Frances M. Ashcroft
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: r.cox@har.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FM CDC FMA APC RDC GSHY SO. Performed the experiments: FM CDC SW LT RL YCLT DR APC. Analyzed the data: FM CDC RL GN APC FMA RDC. Contributed reagents/materials/analysis tools: FB VJ GSHY. Wrote the paper: FM CDC FMA APC RDC.