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Research Article

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

  • Flávia C. Costa,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

    Current address: College of Biosciences, Kansas City University of Medicine and Biosciences, Kansas City, Missouri, United States of America

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  • Halyna Fedosyuk,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Allen M. Chazelle,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Renee Y. Neades,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Kenneth R. Peterson mail

    kpeterson@kumc.edu

    Affiliations: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Published: December 20, 2012
  • DOI: 10.1371/journal.pgen.1003155

About the Authors

Flávia C. Costa, Halyna Fedosyuk, Allen M. Chazelle, Renee Y. Neades, Kenneth R. Peterson
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Kenneth R. Peterson
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: kpeterson@kumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FCC KRP. Performed the experiments: FCC AMC RYN HF. Analyzed the data: FCC AMC KRP. Wrote the paper: FCC KRP.