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Research Article

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

  • Kin Chan,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Joan F. Sterling,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Steven A. Roberts,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Ashok S. Bhagwat,

    Affiliation: Department of Chemistry, Wayne State University, Detroit, Michigan, United States of America

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  • Michael A. Resnick,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Dmitry A. Gordenin mail

    gordenin@niehs.nih.gov

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.pgen.1003149

About the Authors

Kin Chan, Joan F. Sterling, Steven A. Roberts, Michael A. Resnick, Dmitry A. Gordenin
Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
Ashok S. Bhagwat
Department of Chemistry, Wayne State University, Detroit, Michigan, United States of America

Corresponding Author

Email: gordenin@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KC DAG. Performed the experiments: KC SAR. Analyzed the data: KC MAR DAG. Contributed reagents/materials/analysis tools: JFS SAR ASB. Wrote the paper: KC MAR DAG.