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Research Article

Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity

  • Subhajyoti De equal contributor,

    equal contributor Contributed equally to this work with: Subhajyoti De, Rita Shaknovich, Markus Riester

    Affiliations: Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America, Molecular Oncology Program, University of Colorado Cancer Center, Aurora, Colorado, United States of America

    X
  • Rita Shaknovich equal contributor,

    equal contributor Contributed equally to this work with: Subhajyoti De, Rita Shaknovich, Markus Riester

    Affiliations: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Immunopathology, Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Markus Riester equal contributor,

    equal contributor Contributed equally to this work with: Subhajyoti De, Rita Shaknovich, Markus Riester

    Affiliations: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Olivier Elemento,

    Affiliation: Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Huimin Geng,

    Affiliations: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Matthias Kormaksson,

    Affiliation: Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Yanwen Jiang,

    Affiliation: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Bruce Woolcock,

    Affiliation: Centre for Lymphoid Cancers and Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Nathalie Johnson,

    Affiliation: Centre for Lymphoid Cancers and Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Jose M. Polo,

    Affiliation: Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia

    X
  • Leandro Cerchietti,

    Affiliation: Division of Immunopathology, Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America

    X
  • Randy D. Gascoyne,

    Affiliation: Centre for Lymphoid Cancers and Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

    X
  • Ari Melnick mail,

    amm2014@med.cornell.edu (AM); michor@jimmy.harvard.edu (FM)

    Affiliation: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

    These authors also contributed equally to this work.

    X
  • Franziska Michor mail

    amm2014@med.cornell.edu (AM); michor@jimmy.harvard.edu (FM)

    Affiliations: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • Published: January 10, 2013
  • DOI: 10.1371/journal.pgen.1003137

About the Authors

Subhajyoti De
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
Subhajyoti De
Molecular Oncology Program, University of Colorado Cancer Center, Aurora, Colorado, United States of America
Rita Shaknovich, Huimin Geng, Yanwen Jiang, Ari Melnick
Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America
Rita Shaknovich, Leandro Cerchietti
Division of Immunopathology, Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America
Markus Riester, Franziska Michor
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Markus Riester, Franziska Michor
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Olivier Elemento, Huimin Geng
Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America
Matthias Kormaksson
Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College, New York, New York, United States of America
Bruce Woolcock, Nathalie Johnson, Randy D. Gascoyne
Centre for Lymphoid Cancers and Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Jose M. Polo
Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SD RS AM FM. Performed the experiments: SD RS MR. Wrote the paper: SD RS MR OE HG MK YJ BW NJ JMP LC RDG AM FM. Contributed reagents/materials/analysis tools: SD RS MR OE HG MK YJ BW NJ JMP LC RDG AM FM. Analyzed the data: SD RS MR AM FM LC.