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Research Article

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

  • Elisabeth M. Lodder equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Brendon P. Scicluna equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Annalisa Milano,

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Albert Y. Sun,

    Affiliation: The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Hao Tang,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Carol Ann Remme,

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Perry D. Moerland,

    Affiliation: Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Michael W. T. Tanck,

    Affiliation: Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Geoffrey S. Pitt,

    Affiliation: The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Douglas A. Marchuk,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Connie R. Bezzina mail

    C.R.Bezzina@amc.uva.nl

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.pgen.1003113

About the Authors

Elisabeth M. Lodder, Brendon P. Scicluna, Annalisa Milano, Carol Ann Remme, Connie R. Bezzina
Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Albert Y. Sun, Geoffrey S. Pitt
The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America
Hao Tang, Douglas A. Marchuk
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
Perry D. Moerland, Michael W. T. Tanck
Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: C.R.Bezzina@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EML BPS AM AYS HT CAR CRB. Performed the experiments: EML BPS AM AYS HT CAR. Analyzed the data: EML BPS AM AYS HT CAR PDM MWTT GSP DAM. Contributed reagents/materials/analysis tools: GSP DAM. Wrote the paper: EML BPS CRB.