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Research Article

Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme

  • Moshe Dessau equal contributor,

    equal contributor Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Daniel Goldhill equal contributor,

    equal contributor Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    X
  • Robert L. McBride,

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    Current address: Sapphire Energy, San Diego, California, United States of America

    X
  • Paul E. Turner mail,

    paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    X
  • Yorgo Modis mail

    paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003102

About the Authors

Moshe Dessau, Yorgo Modis
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Daniel Goldhill, Robert L. McBride, Paul E. Turner
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MD DG PET YM. Performed the experiments: MD DG RLM YM. Analyzed the data: MD DG RLM PET YM. Wrote the paper: MD DG PET YM.