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Research Article

Genes Contributing to Pain Sensitivity in the Normal Population: An Exome Sequencing Study

  • Frances M. K. Williams,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Serena Scollen,

    Affiliation: Pfizer Limited, Neusentis, Granta Park, Cambridge, United Kingdom

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  • Dandan Cao,

    Affiliation: BGI–Shenzhen, Shenzhen, China

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  • Yasin Memari,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Craig L. Hyde,

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Baohong Zhang,

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Benjamin Sidders,

    Affiliation: Pfizer Limited, Neusentis, Granta Park, Cambridge, United Kingdom

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  • Daniel Ziemek,

    Affiliation: Worldwide R&D, Pfizer, Cambridge, Massachusetts, United States of America

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  • Yujian Shi,

    Affiliation: BGI–Shenzhen, Shenzhen, China

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  • Juliette Harris,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Ian Harrow,

    Affiliation: Pfizer Global Research and Development, Sandwich, United Kingdom

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  • Brian Dougherty,

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Anders Malarstig,

    Affiliation: Pfizer Limited, Neusentis, Granta Park, Cambridge, United Kingdom

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  • Robert McEwen,

    Affiliation: Pfizer Global Research and Development, Sandwich, United Kingdom

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  • Joel C. Stephens,

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Ketan Patel,

    Affiliation: Pfizer Global Research and Development, Sandwich, United Kingdom

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  • Cristina Menni,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • So-Youn Shin,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Dylan Hodgkiss,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Gabriela Surdulescu,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Wen He,

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Xin Jin,

    Affiliations: BGI–Shenzhen, Shenzhen, China, School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China

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  • Stephen B. McMahon,

    Affiliation: Wolfson CARD, King's College London, London, United Kingdom

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  • Nicole Soranzo equal contributor,

    equal contributor Contributed equally to this work with: Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Sally John equal contributor,

    equal contributor Contributed equally to this work with: Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector

    Affiliation: Pfizer Research Laboratories, Groton, Connecticut, United States of America

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  • Jun Wang equal contributor mail,

    equal contributor Contributed equally to this work with: Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector

    wangjun30@gmail.com (JW); tim.spector@kcl.ac.uk (TDS)

    Affiliations: BGI–Shenzhen, Shenzhen, China, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark, Department of Biology, University of Copenhagen, Copenhagen, Denmark

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  • Tim D. Spector equal contributor mail

    equal contributor Contributed equally to this work with: Nicole Soranzo, Sally John, Jun Wang, Tim D. Spector

    wangjun30@gmail.com (JW); tim.spector@kcl.ac.uk (TDS)

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Published: December 20, 2012
  • DOI: 10.1371/journal.pgen.1003095

About the Authors

Frances M. K. Williams, Juliette Harris, Cristina Menni, Dylan Hodgkiss, Gabriela Surdulescu, Tim D. Spector
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Serena Scollen, Benjamin Sidders, Anders Malarstig
Pfizer Limited, Neusentis, Granta Park, Cambridge, United Kingdom
Dandan Cao, Yujian Shi, Xin Jin, Jun Wang
BGI–Shenzhen, Shenzhen, China
Yasin Memari, So-Youn Shin, Nicole Soranzo
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Craig L. Hyde, Baohong Zhang, Brian Dougherty, Joel C. Stephens, Wen He, Sally John
Pfizer Research Laboratories, Groton, Connecticut, United States of America
Daniel Ziemek
Worldwide R&D, Pfizer, Cambridge, Massachusetts, United States of America
Ian Harrow, Robert McEwen, Ketan Patel
Pfizer Global Research and Development, Sandwich, United Kingdom
Xin Jin
School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China
Stephen B. McMahon
Wolfson CARD, King's College London, London, United Kingdom
Jun Wang
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Jun Wang
Department of Biology, University of Copenhagen, Copenhagen, Denmark

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJ TDS FMKW SS CLH BD IH NS SBM. Performed the experiments: YS XJ JW JH GS DH FMKW RM. Analyzed the data: YS NS CLH BZ DZ BS JCS KP CM S-YS. Contributed reagents/materials/analysis tools: YS XJ JW NS YM DZ BS DC WH. Wrote the paper: FMKW SS CLH YM BZ TDS SJ AM JCS SBM.