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Research Article

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

  • Sarah A. Pendergrass,

    Affiliation: Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

    X
  • Kristin Brown-Gentry,

    Affiliation: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

    X
  • Scott Dudek,

    Affiliation: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

    X
  • Alex Frase,

    Affiliation: Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

    X
  • Eric S. Torstenson,

    Affiliation: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Robert Goodloe,

    Affiliation: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

    X
  • Jose Luis Ambite,

    Affiliation: Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

    X
  • Christy L. Avery,

    Affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Steve Buyske,

    Affiliations: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America, Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Petra Bůžková,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Ewa Deelman,

    Affiliation: Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

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  • Megan D. Fesinmeyer,

    Affiliation: Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Gerardo Heiss,

    Affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Lucia A. Hindorff,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Chu-Nan Hsu,

    Affiliation: Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

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  • Rebecca D. Jackson,

    Affiliation: Ohio State University, Columbus, Ohio, United States of America

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  • Charles Kooperberg,

    Affiliation: Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Loic Le Marchand,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

    X
  • Yi Lin,

    Affiliation: Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Tara C. Matise,

    Affiliation: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

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  • Kristine R. Monroe,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Larry Moreland,

    Affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Sungshim L. Park,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

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  • Alex Reiner,

    Affiliations: Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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  • Robert Wallace,

    Affiliation: Departments of Epidemiology and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

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  • Lynn R. Wilkens,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

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  • Dana C. Crawford,

    Affiliations: Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

    X
  • Marylyn D. Ritchie mail

    marylyn.ritchie@psu.edu

    Affiliation: Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America

    X
  • Published: January 31, 2013
  • DOI: 10.1371/journal.pgen.1003087

About the Authors

Sarah A. Pendergrass, Alex Frase, Marylyn D. Ritchie
Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
Kristin Brown-Gentry, Scott Dudek, Eric S. Torstenson, Robert Goodloe, Dana C. Crawford
Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
Jose Luis Ambite, Ewa Deelman, Chu-Nan Hsu
Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America
Christy L. Avery, Gerardo Heiss
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Steve Buyske, Tara C. Matise
Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
Steve Buyske
Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America
Petra Bůžková
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Megan D. Fesinmeyer, Charles Kooperberg, Yi Lin, Alex Reiner
Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Christopher A. Haiman, Kristine R. Monroe
Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Lucia A. Hindorff
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Rebecca D. Jackson
Ohio State University, Columbus, Ohio, United States of America
Loic Le Marchand, Sungshim L. Park, Lynn R. Wilkens
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
Larry Moreland
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Alex Reiner
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Robert Wallace
Departments of Epidemiology and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
Dana C. Crawford
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Author

Email: marylyn.ritchie@psu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAP CK SB DCC MDR JLA CLA ED MDF CAH LAH C-NH RDJ LLM TCM KRM LM AR. Performed the experiments: SAP KB-G SD AF EST RG SB YL SLP. Analyzed the data: SAP KB-G SD AF EST RG SB YL SLP RW. Contributed reagents/materials/analysis tools: SAP SD AF EST RG SB GH CK LRW YL PB SLP. Wrote the paper: SAP JLA CLA SB PB ED MDF CAH GH LAH C-NH RDJ CK LLM YL SLP TCM KRM LM AR RW LRW DCC MDR. Developed the software for the plots in this publication: SAP SD.