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Research Article

Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy

  • Zhiwei Huang,

    Affiliations: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, China

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  • Sankaranarayanan Srinivasan,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Jianhuai Zhang,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Kaifu Chen,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Yongxiang Li,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Wei Li,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Florante A. Quiocho,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Xuewen Pan mail

    xuewenp@bcm.edu

    Affiliations: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center of Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003083

About the Authors

Zhiwei Huang, Sankaranarayanan Srinivasan, Jianhuai Zhang, Yongxiang Li, Florante A. Quiocho, Xuewen Pan
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Zhiwei Huang
Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, China
Kaifu Chen, Wei Li
Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
Kaifu Chen, Wei Li
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Xuewen Pan
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Xuewen Pan
Center of Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: xuewenp@bcm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XP. Performed the experiments: ZH SS JZ YL XP. Analyzed the data: ZH SS KC WL XP. Contributed reagents/materials/analysis tools: ZH YL. Wrote the paper: SS FAQ XP.