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Research Article

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

  • Laura C. Greaves mail,

    laura.greaves@ncl.ac.uk

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Joanna L. Elson,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Marco Nooteboom,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • John P. Grady,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Geoffrey A. Taylor,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Robert W. Taylor,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • John C. Mathers,

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Human Nutrition Research Centre, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom

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  • Thomas B. L. Kirkwood,

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom

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  • Doug M. Turnbull

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003082

About the Authors

Laura C. Greaves, John C. Mathers, Thomas B. L. Kirkwood, Doug M. Turnbull
Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
Laura C. Greaves, Marco Nooteboom, John P. Grady, Geoffrey A. Taylor, Robert W. Taylor, Doug M. Turnbull
Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
Joanna L. Elson
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
John C. Mathers
Human Nutrition Research Centre, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom
Thomas B. L. Kirkwood
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom

Corresponding Author

Email: laura.greaves@ncl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LCG JLE DMT JCM TBLK. Performed the experiments: LCG MN GAT. Analyzed the data: LCG JLE JPG RWT. Contributed reagents/materials/analysis tools: JCM. Wrote the paper: LCG JLE MN JPG GAT RWT JCM TBLK DMT. Statistical analysis: JLE JPG.