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Research Article

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

  • Geeta N. Eick,

    Affiliations: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America, Howard Hughes Medical Institute, Eugene, Oregon, United States of America

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  • Jennifer K. Colucci,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Michael J. Harms,

    Affiliation: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America

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  • Eric A. Ortlund,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Joseph W. Thornton mail

    joet1@uchicago.edu

    Affiliations: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America, Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Department of Human Genetics and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003072

About the Authors

Geeta N. Eick, Michael J. Harms, Joseph W. Thornton
Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America
Geeta N. Eick, Joseph W. Thornton
Howard Hughes Medical Institute, Eugene, Oregon, United States of America
Jennifer K. Colucci, Eric A. Ortlund
Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America
Joseph W. Thornton
Department of Human Genetics and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: joet1@uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWT GNE JKC MJH EAO. Performed the experiments: GNE JKC MJH. Analyzed the data: GNE JKC MJH JWT EAO. Wrote the paper: JWT GNE MJH JKC EAO.