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Research Article

Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression, and Risk of Neural Tube Defects in Mice

  • Sandra C. P. De Castro,

    Affiliation: Neural Development Unit, UCL Institute of Child Health, University College London, London, United Kingdom

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  • Ashraf Malhas,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Kit-Yi Leung,

    Affiliation: Neural Development Unit, UCL Institute of Child Health, University College London, London, United Kingdom

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  • Peter Gustavsson,

    Affiliation: Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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  • David J. Vaux,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Andrew J. Copp,

    Affiliation: Neural Development Unit, UCL Institute of Child Health, University College London, London, United Kingdom

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  • Nicholas D. E. Greene mail

    n.greene@ucl.ac.uk

    Affiliation: Neural Development Unit, UCL Institute of Child Health, University College London, London, United Kingdom

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003059

About the Authors

Sandra C. P. De Castro, Kit-Yi Leung, Andrew J. Copp, Nicholas D. E. Greene
Neural Development Unit, UCL Institute of Child Health, University College London, London, United Kingdom
Ashraf Malhas, David J. Vaux
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Peter Gustavsson
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

Corresponding Author

Email: n.greene@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SCPDC AM DJV AJC NDEG. Performed the experiments: SCPDC AM K-YL PG NDEG. Analyzed the data: SCPDC NDEG AM K-YL PG. Wrote the paper: NDEG AJC SCPDC.