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Research Article

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems

  • Josep M. Mercader,

    Affiliation: Joint IRB–BSC Program on Computational Biology, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain

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  • Montserrat Puiggros,

    Affiliations: Joint IRB–BSC Program on Computational Biology, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain, Computational Bioinformatics, National Institute of Bioinformatics, Madrid, Spain

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  • Ayellet V. Segrè,

    Affiliations: Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Evarist Planet,

    Affiliation: Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain

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  • Eleonora Sorianello,

    Affiliation: Institute for Research in Biomedicine, Universitat de Barcelona, and CIBERDEM, Barcelona, Spain

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  • David Sebastian,

    Affiliation: Institute for Research in Biomedicine, Universitat de Barcelona, and CIBERDEM, Barcelona, Spain

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  • Sergio Rodriguez-Cuenca,

    Affiliation: University of Cambridge, Metabolic Research Laboratories Institute of Metabolic Sciences, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Vicent Ribas,

    Affiliation: Institute for Research in Biomedicine, Universitat de Barcelona, and CIBERDEM, Barcelona, Spain

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  • Sílvia Bonàs-Guarch,

    Affiliation: Joint IRB–BSC Program on Computational Biology, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain

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  • Sorin Draghici,

    Affiliation: Department of Computer Science, Department of Clinical and Translational Science, Department of Obstetrics and Gynecology, and Intelligent Systems and Bioinformatics Laboratory, Wayne State University, Detroit, Michigan, United States of America

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  • Chenjing Yang,

    Affiliation: Institute of Translational Medicine, Cellular and Molecular Physiology, Liverpool, United Kingdom

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  • Sílvia Mora,

    Affiliation: Institute of Translational Medicine, Cellular and Molecular Physiology, Liverpool, United Kingdom

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  • Antoni Vidal-Puig,

    Affiliation: University of Cambridge, Metabolic Research Laboratories Institute of Metabolic Sciences, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Josée Dupuis,

    Affiliations: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

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  • DIAGRAM Consortium ,

    Memberships of the consortia are provided in Appendix S1.

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  • Jose C. Florez,

    Affiliations: Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Diabetes Unit, Center for Human Genetic Research and Diabetes Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • MITIN Consortium ,

    Memberships of the consortia are provided in Appendix S1.

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  • Antonio Zorzano,

    Affiliation: Institute for Research in Biomedicine, Universitat de Barcelona, and CIBERDEM, Barcelona, Spain

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  • David Torrents mail

    david.torrents@bsc.es

    Affiliations: Joint IRB–BSC Program on Computational Biology, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA) Barcelona, Spain

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.pgen.1003046

About the Authors

Josep M. Mercader, Montserrat Puiggros, Sílvia Bonàs-Guarch, David Torrents
Joint IRB–BSC Program on Computational Biology, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain
Montserrat Puiggros
Computational Bioinformatics, National Institute of Bioinformatics, Madrid, Spain
Ayellet V. Segrè
Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Ayellet V. Segrè, Jose C. Florez
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
Evarist Planet
Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain
Eleonora Sorianello, David Sebastian, Vicent Ribas, Antonio Zorzano
Institute for Research in Biomedicine, Universitat de Barcelona, and CIBERDEM, Barcelona, Spain
Sergio Rodriguez-Cuenca, Antoni Vidal-Puig
University of Cambridge, Metabolic Research Laboratories Institute of Metabolic Sciences, Addenbrooke's Hospital, Cambridge, United Kingdom
Sorin Draghici
Department of Computer Science, Department of Clinical and Translational Science, Department of Obstetrics and Gynecology, and Intelligent Systems and Bioinformatics Laboratory, Wayne State University, Detroit, Michigan, United States of America
Chenjing Yang, Sílvia Mora
Institute of Translational Medicine, Cellular and Molecular Physiology, Liverpool, United Kingdom
Josée Dupuis
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Josée Dupuis
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America
Jose C. Florez
Diabetes Unit, Center for Human Genetic Research and Diabetes Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Jose C. Florez
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
David Torrents
Institució Catalana de Recerca i Estudis Avançats (ICREA) Barcelona, Spain

Corresponding Author

Email: david.torrents@bsc.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMM DT JCF AZ AV-P SM. Performed the experiments: JMM MP AVS SR-C VR CY SM. Analyzed the data: JMM MP AVS EP JD SB-G SD ES DS. Contributed reagents/materials/analysis tools: AVS JD. Wrote the paper: JMM ES DS SM AV-P AZ DT.