Advertisement
Research Article

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

  • John P. Miller,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Bridget E. Yates,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Ismael Al-Ramahi,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Ari E. Berman,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Mario Sanhueza,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Eugene Kim,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Maria de Haro,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Francesco DeGiacomo,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Cameron Torcassi,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Jennifer Holcomb,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Juliette Gafni,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Sean D. Mooney,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Juan Botas,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Lisa M. Ellerby mail,

    lellerby@buckinstitute.org (LME); rhughes@buckinstitute.org (REH)

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Robert E. Hughes mail

    lellerby@buckinstitute.org (LME); rhughes@buckinstitute.org (REH)

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003042

About the Authors

John P. Miller, Bridget E. Yates, Ari E. Berman, Francesco DeGiacomo, Cameron Torcassi, Jennifer Holcomb, Juliette Gafni, Sean D. Mooney, Lisa M. Ellerby, Robert E. Hughes
The Buck Institute for Research on Aging, Novato, California, United States of America
Ismael Al-Ramahi, Mario Sanhueza, Eugene Kim, Maria de Haro, Juan Botas
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPM BEY IA-R AEB SDM JB LME REH. Performed the experiments: JPM BEY IA-R AEB MS EK MdH FD CT JH JG LME. Analyzed the data: JPM BEY IA-R AEB FD JG SDM JB LME REH. Contributed reagents/materials/analysis tools: SDM JB LME REH. Wrote the paper: JPM BEY IA-R AEB JB LME REH.