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Research Article

Cooperativity of Rb, Brca1, and p53 in Malignant Breast Cancer Evolution

  • Prashant Kumar,

    Affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Malini Mukherjee,

    Affiliation: Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Jacob P. S. Johnson,

    Affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Milan Patel,

    Affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Bing Huey,

    Affiliation: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Donna G. Albertson,

    Affiliation: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Karl Simin mail

    karl.simin@umassmed.edu

    Affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003027

About the Authors

Prashant Kumar, Jacob P. S. Johnson, Milan Patel, Karl Simin
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Malini Mukherjee
Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
Bing Huey, Donna G. Albertson
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: karl.simin@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PK MM KS. Performed the experiments: PK MM MP KS. Analyzed the data: PK MM JPSJ KS. Contributed reagents/materials/analysis tools: PK KS DGA BH. Wrote the paper: JPSJ KS.