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Research Article

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

  • Carsten Merkwirth,

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany

    Current address: The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Paola Martinelli equal contributor,

    equal contributor Contributed equally to this work with: Paola Martinelli, Anne Korwitz

    Affiliation: Institute for Zoology, University of Cologne, Cologne, Germany

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  • Anne Korwitz equal contributor,

    equal contributor Contributed equally to this work with: Paola Martinelli, Anne Korwitz

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany

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  • Michela Morbin,

    Affiliation: Neuropathology and Neurology 5, IRCCS Foundation, Neurological Institute Carlo Besta, Milano, Italy

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  • Hella S. Brönneke,

    Affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

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  • Sabine D. Jordan,

    Affiliation: Institute for Genetics, University of Cologne, Cologne, Germany

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  • Elena I. Rugarli,

    Affiliations: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany, Institute for Zoology, University of Cologne, Cologne, Germany

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  • Thomas Langer mail

    Thomas.Langer@uni-koeln.de

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany, Max Planck Institute for Biology of Aging, Cologne, Germany

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pgen.1003021

About the Authors

Carsten Merkwirth, Anne Korwitz, Sabine D. Jordan, Thomas Langer
Institute for Genetics, University of Cologne, Cologne, Germany
Carsten Merkwirth, Anne Korwitz, Hella S. Brönneke, Elena I. Rugarli, Thomas Langer
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
Carsten Merkwirth, Anne Korwitz, Elena I. Rugarli, Thomas Langer
Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany
Paola Martinelli, Elena I. Rugarli
Institute for Zoology, University of Cologne, Cologne, Germany
Michela Morbin
Neuropathology and Neurology 5, IRCCS Foundation, Neurological Institute Carlo Besta, Milano, Italy
Thomas Langer
Max Planck Institute for Biology of Aging, Cologne, Germany

Corresponding Author

Email: Thomas.Langer@uni-koeln.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CM PM AK HSB EIR TL. Performed the experiments: CM PM AK MM HSB SDJ. Analyzed the data: CM PM AK MM HSB SDJ. Wrote the paper: CM EIR TL.