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Research Article

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

  • Scott A. Lujan,

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Jessica S. Williams,

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

    X
  • Zachary F. Pursell,

    Affiliation: Department of Biochemistry, Tulane University, New Orleans, Louisiana, United States of America

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  • Amy A. Abdulovic-Cui,

    Affiliation: Department of Biology, Augusta State University, Augusta, Georgia, United States of America

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  • Alan B. Clark,

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Stephanie A. Nick McElhinny,

    Affiliation: United States Army Research Office, Research Triangle Park, North Carolina, United States of America

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  • Thomas A. Kunkel mail

    kunkel@niehs.nih.gov

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1003016

About the Authors

Scott A. Lujan, Jessica S. Williams, Alan B. Clark, Thomas A. Kunkel
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
Zachary F. Pursell
Department of Biochemistry, Tulane University, New Orleans, Louisiana, United States of America
Amy A. Abdulovic-Cui
Department of Biology, Augusta State University, Augusta, Georgia, United States of America
Stephanie A. Nick McElhinny
United States Army Research Office, Research Triangle Park, North Carolina, United States of America

Corresponding Author

Email: kunkel@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAL JSW ZFP AAA-C ABC SANM TAK. Performed the experiments: SAL JSW ZFP AAA-C ABC SANM. Analyzed the data: SAL JSW ZFP AAA-C ABC SANM TAK. Contributed reagents/materials/analysis tools: SAL JSW ZFP AAA-C ABC SANM TAK. Wrote the paper: SAL JSW TAK. Designed the software tools used in analysis: SAL.